Bornstein S R, Preas H L, Chrousos G P, Suffredini A F
Pediatric Endocrinology Section, Developmental Endocrinology Branch, National Institute of Child Health and Human Development and Critical Care Medicine, National Institutes of Health Clinical Center, National Institutes of Health.
J Infect Dis. 1998 Sep;178(3):887-90. doi: 10.1086/515349.
Leptin, a newly discovered adipose tissue-derived weight-reducing hormone, is increased in acute inflammation and may be involved in the anorexia and wasting syndrome associated with infection. To determine whether this hormone responds to an acute inflammatory stimulus, plasma leptin concentrations were measured in 12 healthy subjects after intravenous administration of endotoxin. These subjects were randomized to receive concurrently ibuprofen or placebo normal saline (6 in each group). Endotoxin administration resulted in fever, leukocytosis, and an increase in plasma levels of the stress hormones adrenocorticotropic hormone (3.2 +/- 0.3 to 132.6 +/- 75.5 pmol/L, P = .001) and cortisol (431.6 +/- 44 to 796.9 +/- 99 mmol/L, P = .001). Plasma leptin levels, however, did not change significantly from baseline values after administration of endotoxin (0 h: 6.9 +/- 3.1 ng/mL; 6 h: 6.0 +/- 2.2; 24 h: 6.5 +/- 2.8). While ibuprofen suppressed fever and symptoms associated with endotoxemia, it had no effect on the plasma levels of leptin. In conclusion, acute experimental human endotoxinemia is not associated with acute changes in circulating leptin levels.
瘦素是一种新发现的由脂肪组织产生的减肥激素，在急性炎症时会升高，可能与感染相关的厌食和消瘦综合征有关。为了确定这种激素是否对急性炎症刺激有反应，在12名健康受试者静脉注射内毒素后测量了血浆瘦素浓度。这些受试者被随机分组，同时接受布洛芬或安慰剂生理盐水（每组6人）。注射内毒素导致发热、白细胞增多，以及应激激素促肾上腺皮质激素（从3.2±0.3皮摩尔/升升至132.6±75.5皮摩尔/升，P = .001）和皮质醇（从431.6±44毫摩尔/升升至796.9±99毫摩尔/升，P = .001）的血浆水平升高。然而，注射内毒素后血浆瘦素水平与基线值相比没有显著变化（0小时：6.9±3.1纳克/毫升；6小时：6.0±2.2；24小时：6.5±2.8）。虽然布洛芬抑制了发热和与内毒素血症相关的症状，但它对瘦素的血浆水平没有影响。总之，急性实验性人类内毒素血症与循环瘦素水平的急性变化无关。
