东南亚丙型肝炎病毒血清分型检测方法
A serotyping assay for hepatitis C virus in Southeast Asia.
作者信息
Songsivilai S, Kanistanon D, Dharakul T
机构信息
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
出版信息
Clin Diagn Lab Immunol. 1998 Sep;5(5):737-9. doi: 10.1128/CDLI.5.5.737-739.1998.
A serotyping assay for hepatitis C virus (HCV) was evaluated with samples from Thailand, where the distribution of HCV genotypes was different from that in Western countries where the assay was designed and validated. The sensitivity of the assay was low (58%) for HCV RNA-positive samples compared to that of the genotyping assay (95%, P < 0.01). In addition, only 36% of anti-HCV-positive but HCV RNA-negative samples could be serotyped. The serotypes and genotypes were identical in 96% of the samples that could be typed by both methods. Most of the samples with genotype 6, which was common in Southeast Asia, were nontypeable by this serotyping assay.
使用来自泰国的样本对丙型肝炎病毒（HCV）血清分型检测方法进行了评估，泰国HCV基因型的分布与该检测方法设计和验证所在的西方国家不同。与基因分型检测方法（95%，P < 0.01）相比，该检测方法对HCV RNA阳性样本的敏感性较低（58%）。此外，抗HCV阳性但HCV RNA阴性的样本中只有36%能够进行血清分型。两种方法均可分型的样本中，96%的样本血清型和基因型相同。东南亚常见的基因型6的大多数样本无法通过这种血清分型检测方法进行分型。
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