Barbera N, Bulla G, Romano G
Institute of Legal Medicine, University of Catania, Italy.
J Forensic Sci. 1998 Nov;43(6):1250-1.
Chronic effects following repeated exposure to low doses of benzene have been well assessed, whereas few data are available about acute exposure to benzene. We report a case of fatal acute intoxication which occurred aboard a chemical cargo ship. Autopsy findings included blood clots inside the heart and main vessels, multi-organ congestion, pulmonary edema and the presence of many vibices in the hypostatic areas. Toxicological analysis of blood and urine showed a benzene concentration of 31.67 and 2.26 micrograms/mL, respectively; high concentrations of benzene (microgram/g) were also found in the lungs (22.23), liver (378.60), brain (178.66), heart (182.57) and kidneys (75.15). The above data provide evidence for benzene distribution in various organs.
反复接触低剂量苯后的慢性影响已得到充分评估，而关于急性接触苯的数据却很少。我们报告了一例发生在一艘化学品货船上的致命急性中毒病例。尸检结果包括心脏和主要血管内的血凝块、多器官充血、肺水肿以及坠积部位出现许多瘀斑。血液和尿液的毒理学分析显示，苯浓度分别为31.67微克/毫升和2.26微克/毫升；在肺（22.23）、肝（378.60）、脑（178.66）、心脏（182.57）和肾（75.15）中也发现了高浓度的苯（微克/克）。上述数据为苯在各器官中的分布提供了证据。
