A fatal case of benzene poisoning.

Chronic effects following repeated exposure to low doses of benzene have been well assessed, whereas few data are available about acute exposure to benzene. We report a case of fatal acute intoxication which occurred aboard a chemical cargo ship. Autopsy findings included blood clots inside the heart and main vessels, multi-organ congestion, pulmonary edema and the presence of many vibices in the hypostatic areas. Toxicological analysis of blood and urine showed a benzene concentration of 31.67 and 2.26 micrograms/mL, respectively; high concentrations of benzene (microgram/g) were also found in the lungs (22.23), liver (378.60), brain (178.66), heart (182.57) and kidneys (75.15). The above data provide evidence for benzene distribution in various organs.