Charlton M, Adjei P, Poterucha J, Zein N, Moore B, Therneau T, Krom R, Wiesner R
Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Hepatology. 1998 Sep;28(3):839-42. doi: 10.1002/hep.510280335.
A novel DNA virus, TT-virus (TTV), has been reported in patients with non-A-G posttransfusion hepatitis in Japan. We sought to determine whether TTV infection occurs in North American blood donors and to further determine the prevalence of TTV infection in several groups of patients with liver disease, including patients with cryptogenic cirrhosis and idiopathic fulminant hepatic failure. TTV infection was sought by detection of TTV DNA in serum by polymerase chain reaction (PCR) using primers generated from a conserved region of the TTV genome. Blood donors, patients with cryptogenic cirrhosis, idiopathic fulminant hepatic failure, and patients with other forms of advanced liver disease with and without a history of parenteral exposures were studied. TTV infection was present in 1% (1 of 100) of blood donors, 15% (5 of 33) of patients with cryptogenic cirrhosis, 27% (3 of 11) of patients with idiopathic fulminant hepatic failure, 18% (2 of 11) of patients with a history of exposure to blood products, and 4% (1 of 25) of patients without parenteral risk factors. For all patients tested, a history of prior exposure to blood products was associated with an increased risk of TTV infection (relative risk, 4.5; 90% confidence intervals, 0.6-43.9). We conclude that TTV infection is present among North American blood donors and is common in patients with liver disease, including cryptogenic cirrhosis and fulminant hepatic failure. Further studies are required to determine the role of TTV in the pathogenicity of acute and/or chronic liver disease.
在日本，已在非甲 - 非戊型输血后肝炎患者中发现一种新型DNA病毒——TT病毒（TTV）。我们试图确定北美献血者中是否存在TTV感染，并进一步确定TTV感染在几组肝病患者中的流行情况，这些患者包括隐源性肝硬化患者和特发性暴发性肝衰竭患者。通过使用从TTV基因组保守区域生成的引物，采用聚合酶链反应（PCR）检测血清中的TTV DNA来寻找TTV感染。我们研究了献血者、隐源性肝硬化患者、特发性暴发性肝衰竭患者以及有或无肠外暴露史的其他晚期肝病患者。TTV感染在1%（100例中的1例）的献血者、15%（33例中的5例）的隐源性肝硬化患者、27%（11例中的3例）的特发性暴发性肝衰竭患者、18%（11例中的2例）有血液制品接触史的患者以及4%（25例中的1例）无肠外风险因素的患者中存在。对于所有检测的患者，既往有血液制品接触史与TTV感染风险增加相关（相对风险为4.5；90%置信区间为0.6 - 43.9）。我们得出结论，TTV感染在北美献血者中存在，并且在肝病患者中常见，包括隐源性肝硬化和暴发性肝衰竭患者。需要进一步研究以确定TTV在急性和/或慢性肝病致病性中的作用。
