Spitzer M
Department of Obstetrics and Gynecology, Queens Hospital Center affiliated with the Mount Sinai School of Medicine, Jamaica, New York 11432, USA.
Am J Obstet Gynecol. 1998 Aug;179(2):544-56. doi: 10.1016/s0002-9378(98)70393-x.
In an effort to reduce the false-negative rate of cervical cytologic findings, several new technologies have recently evolved. Automated cytologic testing (PapNet, AutoPap 300 QC) proposes to rescreen negative conventional cytologic findings to identify smears likely to be false negative. Fluid-based monolayers (ThinPrep, CytoRich) propose to reduce the false-negative rates by optimizing the collection and preparation of cells. Human papillomavirus deoxyribonucleic acid testing by Hybrid Capture has been proposed for a variety of screening and triage roles. Visual screening after application of acetic acid is done by cervicography by use of a photographic technique, whereas in speculoscopy the screening is done by direct visualization of the cervix by the primary care provider. Polarprobe uses biophysical parameters and a computer algorithm to give an instantaneous prediction of the likelihood of cervical disease. Each of these techniques, as well as the clinical experience with them, is reviewed. Current and possible future uses are discussed with regard to both clinical usefulness and cost-effectiveness.
为了降低宫颈细胞学检查结果的假阴性率，最近出现了几种新技术。自动细胞学检测（PapNet、AutoPap 300 QC）提议对常规细胞学阴性结果进行重新筛查，以识别可能为假阴性的涂片。液基单层制片技术（ThinPrep、CytoRich）提议通过优化细胞采集和制片来降低假阴性率。通过杂交捕获法进行人乳头瘤病毒脱氧核糖核酸检测已被用于多种筛查和分流作用。应用醋酸后的视觉筛查通过宫颈摄影术利用摄影技术完成，而在阴道镜检查中，由初级保健提供者直接观察宫颈进行筛查。Polarprobe使用生物物理参数和计算机算法来即时预测宫颈疾病的可能性。对这些技术及其临床经验进行了综述。就临床实用性和成本效益讨论了其当前和未来可能的用途。
