Yoshikawa K, Matsuchika K, Arihara S, Chang H C, Wang J D
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1239-43. doi: 10.1248/cpb.46.1239.
The structural elucidation of six new related polyoxypregnane glycosides, gymnepregosides A (1), B (2), C (3), D (4), E (5) and F (6), together with two known compounds, from the roots of Gymnema alternifolium (Asclepiadaceae) was achieved through on a detailed study of 1H- and 13C-NMR spectral data and chemical means. The results obtained for new compounds, 1-6, show that they are (20S)-pregn-6-ene-3 beta,5 alpha,8 beta,12 beta,14 beta,17 beta,20-heptaol or sarcostin 3-O-glycosides, and all the sugars at C-3 are beta(1-->4)-linked. Some of them possessed benzoyl, cinnamoyl and tigloyl residues as the ester linkages located at C-12 and/or C-20 of the aglycon.
通过对1H-和13C-NMR光谱数据的详细研究及化学方法，从匙羹藤（萝摩科）根中鉴定出6个新的相关多氧孕甾烷糖苷，匙羹藤苷A（1）、B（2）、C（3）、D（4）、E（5）和F（6），以及2个已知化合物。新化合物1 - 6的研究结果表明，它们是（20S）-孕甾-6-烯-3β，5α，8β，12β，14β，17β，20-庚醇或肉珊瑚苷元3-O-糖苷，且C-3位的所有糖均为β（1→4）连接。其中一些在苷元的C-12和/或C-20位具有苯甲酰基、肉桂酰基和惕各酰基残基作为酯键。
