Juergens U R, Stöber M, Schmidt-Schilling L, Kleuver T, Vetter H
Abteilung Pneumologie, Medizinische Universitäts-Poliklinik Bonn, Wilhelmstrasse 35-37, D-53111 Bonn, Germany.
Eur J Med Res. 1998 Sep 17;3(9):407-12.
Monoterpenes are prescribed to treat chronic obstructive airway disorders mainly because of their familiar secretolytic properties. The aim of this study was to investigate the effect of 1.8-cineole (Soledum) on arachidonic acid (AA) metabolism in blood monocytes of patients with bronchial asthma. Patients with bronchial asthma (n = 10) and healthy test subjects (n = 12) were included in the study. Production of the representative AA-metabolites LTB4 and PGE2 from isolated monocytes stimulated with the calcium ionophore A23187 were measured ex vivo before therapy with 1.8-cineole (3 x 200 mg/day), after three days of treatment (day 4) and four days after discontinuation of 1. 8-cineole (day 8). The production of LTB4 and PGE2 from monocytes ex vivo was significantly inhibited on day 4 in patients with bronchial asthma (-40.3%, n = 10 and -31.3%, p = 0.1, n = 3 respectively) as well as in healthy volunteers (-57.9%, n = 12 and -42.7%, n = 8 respectively). In conclusion, 1.8-cineole was shown to inhibit LTB4 and PGE2, both pathways of AA-metabolism. Further studies are needed to show that 1.8-cineole is suitable in the treatment of bronchial asthma.
单萜类药物被用于治疗慢性阻塞性气道疾病，主要是因为其为人熟知的促分泌特性。本研究的目的是调查1,8-桉叶素（Soledum）对支气管哮喘患者血液单核细胞中花生四烯酸（AA）代谢的影响。本研究纳入了支气管哮喘患者（n = 10）和健康受试者（n = 12）。在用1,8-桉叶素（3×200mg/天）治疗前、治疗三天后（第4天）以及停用1,8-桉叶素四天后（第8天），离体测量用钙离子载体A23187刺激分离出的单核细胞产生代表性AA代谢物白三烯B4（LTB4）和前列腺素E2（PGE2）的情况。支气管哮喘患者（分别为-40.3%，n = 10和-31.3%，p = 0.1，n = 3）以及健康志愿者（分别为-57.9%，n = 12和-42.7%，n = 8）在第4天时，离体单核细胞产生LTB4和PGE2的量均显著受到抑制。总之，结果显示1,8-桉叶素可抑制AA代谢的LTB4和PGE2两条途径。需要进一步研究来证明1,8-桉叶素适用于支气管哮喘的治疗。
