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标准桃金娘油对炎症和过敏介质的干扰作用。

Interference of myrtol standardized with inflammatory and allergic mediators.

作者信息

Beuscher N, Kietzmann M, Bien E, Champeroux P

机构信息

G. Pohl-Boskamp GmbH & Co., Hohenlockstedt, Germany.

出版信息

Arzneimittelforschung. 1998 Oct;48(10):985-9.

PMID:9825115
Abstract

Myrtol standardized (Gelomyrtol/Gelomyrtol forte) inhibits the activity of 5-lipoxygenase of human basophil and eosinophil leukocytes and the formation of leukotriene C4 as well as 1.8-cineole (eucalyptol). An increase of prostaglandins (PGE2) in mucous membranes of teat cisterns after topical administration of TPA (tetradecanoylphorbol-13-acetate) was inhibited. In vitro and in vivo studies revealed spasmolytic and broncholytic effects of Myrtol stand. After topical administration into the teat cisterns of the isolated bovine udder Myrtol stand. increased the surface temperature, comparable to effects of menthol.

摘要

标准桃金娘油(吉诺通/强力吉诺通)可抑制人嗜碱性粒细胞和嗜酸性粒细胞的5-脂氧合酶活性以及白三烯C4的形成,同时还含有1,8-桉叶素(桉油醇)。局部应用佛波酯(十四酰佛波醇-13-乙酸酯)后,乳头池黏膜中前列腺素(PGE2)的增加受到抑制。体外和体内研究表明,标准桃金娘油具有解痉和支气管溶解作用。将标准桃金娘油局部应用于离体牛乳房的乳头池后,其可提高表面温度,与薄荷醇的作用相当。

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