Juergens U R, Stöber M, Vetter H
Abteilung Pneumologie, Medizinische Universitäts-Poliklinik Bonn, Wilhelmstrasse 35-37, D-53111 Bonn, Germany.
Eur J Med Res. 1998 Nov 17;3(11):508-10.
Cineole (eucalyptol) is the isolated active agent of eucalyptus oil. Traditionally, it is recommended for treating the symptoms of airway diseases exacerbated by infection. We have examined the inhibitory effect of 1.8-cineole on LPS-and IL1beta-stimulated mediator production by human monocytes in vitro. For the first time, we report on a dose-dependent and highly significant inhibition of production of tumor necrosis factor-alpha, interleukin-1beta, leukotriene B4 and thromboxane B2 by 1.8-cineole. In summary, this is the first report on a new mechanism of action of monoterpenes suggesting 1.8-cineole as a strong inhibitor of cytokines that might be suitable for longterm treatment of airway inflammation in bronchial asthma and other steroid-sensitive disorders.
桉叶油素（1,8-桉叶素）是从桉树叶中提取的活性成分。传统上，它被推荐用于治疗因感染引起的气道疾病症状。我们已经在体外研究了1,8-桉叶素对脂多糖（LPS）和白细胞介素-1β（IL-1β）刺激的人单核细胞介质产生的抑制作用。我们首次报道了1,8-桉叶素对肿瘤坏死因子-α、白细胞介素-1β、白三烯B4和血栓素B2产生的剂量依赖性和高度显著的抑制作用。总之，这是关于单萜类新作用机制的首次报道，表明1,8-桉叶素是细胞因子的强效抑制剂，可能适用于支气管哮喘和其他类固醇敏感疾病的气道炎症的长期治疗。
