Rohner P, Jahn E I, Ninet B, Ionati C, Weber R, Auckenthaler R, Pfyffer G E
Infectious Disease Division, Bacteriology Laboratory, University Hospital Geneva, 1211 Geneva, Switzerland.
J Clin Microbiol. 1998 Oct;36(10):3046-7. doi: 10.1128/JCM.36.10.3046-3047.1998.
The LCx MTB amplification assay is a nucleic acid amplification test intended for the direct detection of Mycobacterium tuberculosis complex in respiratory specimens. We evaluated its performance on 2,001 consecutive respiratory specimens; 78 were culture positive for M. tuberculosis. Sensitivity, specificity, and positive and negative predictive values of this assay for all specimens compared to culture results were 88.5, 97.7, 60.5, and 99.5%, respectively. When referred to resolved clinical diagnosis of active tuberculosis, these values improved to 90.2, 98.4, 72.8, and 99.5%, respectively.
左冠状动脉回旋支（LCx）结核分枝杆菌（MTB）扩增检测是一种核酸扩增试验，旨在直接检测呼吸道标本中的结核分枝杆菌复合群。我们对2001份连续呼吸道标本评估了其性能；78份标本结核分枝杆菌培养呈阳性。与培养结果相比，该检测对所有标本的敏感性、特异性、阳性预测值和阴性预测值分别为88.5%、97.7%、60.5%和99.5%。当参考活动性结核的明确临床诊断时，这些值分别提高到90.2%、98.4%、72.8%和99.5%。
