Markenson G R, Yancey M K
Division of Maternal-Fetal Medicine, Baystate Medical Center, Springfield, MA, USA.
Semin Perinatol. 1998 Aug;22(4):309-17. doi: 10.1016/s0146-0005(98)80019-0.
Parvovirus B19 is the viral agent that causes the childhood exanthum erythema infectiosum, or fifth disease. Approximately 50% of pregnant women are seropositive for this agent and thus immune to primary infection. However, acute infection may develop in seronegative pregnant women exposed to B19. Acute B19 infections during pregnancy have been associated with miscarriage and hydrops fetalis. This latter condition is amenable to fetal therapy via intrauterine transfusion.
细小病毒B19是引发儿童传染性红斑（即第五病）的病毒病原体。大约50%的孕妇对此病原体血清呈阳性，因此对原发性感染具有免疫力。然而，血清反应阴性的孕妇若接触到B19，可能会发生急性感染。孕期急性B19感染与流产和胎儿水肿有关。后一种情况可通过宫内输血进行胎儿治疗。
