利福平与异烟肼联合使用时的血清浓度及生物利用度。
Serum concentrations and bioavailability of rifampicin and isoniazid in combination.
作者信息
Garnham J C, Taylor T, Turner P, Chasseaud L F
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):897-902. doi: 10.1111/j.1365-2125.1976.tb00644.x.
Abstract
The bioavailability of rifampicin and isoniazid from formulations containing these drugs in combination has been compared to that from formulations containing either drug alone. No formulation-related differences in either rates or extent of bioavailability were found after administration of each formulation. Mean peak serum concentrations of rifampicin (8.2-11.7 mug/ml) occurring 2 to 4 h after doses of 600 mg, and isoniazid (3.6-4.8 mug/ml) occurring 0.5 to 1 h after doses of 300 mg, were similar to those reported in the literature.
摘要
已将含有利福平与异烟肼联合制剂的生物利用度与含有单一药物制剂的生物利用度进行了比较。给予每种制剂后，未发现生物利用度的速率或程度存在与制剂相关的差异。利福平在600mg剂量给药后2至4小时出现的平均血清峰值浓度（8.2 - 11.7μg/ml），以及异烟肼在300mg剂量给药后0.5至1小时出现的平均血清峰值浓度（3.6 - 4.8μg/ml），与文献报道的相似。
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