利福平与异烟肼联合使用时的血清浓度及生物利用度。
Serum concentrations and bioavailability of rifampicin and isoniazid in combination.
作者信息
Garnham J C, Taylor T, Turner P, Chasseaud L F
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):897-902. doi: 10.1111/j.1365-2125.1976.tb00644.x.
Abstract
The bioavailability of rifampicin and isoniazid from formulations containing these drugs in combination has been compared to that from formulations containing either drug alone. No formulation-related differences in either rates or extent of bioavailability were found after administration of each formulation. Mean peak serum concentrations of rifampicin (8.2-11.7 mug/ml) occurring 2 to 4 h after doses of 600 mg, and isoniazid (3.6-4.8 mug/ml) occurring 0.5 to 1 h after doses of 300 mg, were similar to those reported in the literature.
摘要
已将含有利福平与异烟肼联合制剂的生物利用度与含有单一药物制剂的生物利用度进行了比较。给予每种制剂后，未发现生物利用度的速率或程度存在与制剂相关的差异。利福平在600mg剂量给药后2至4小时出现的平均血清峰值浓度（8.2 - 11.7μg/ml），以及异烟肼在300mg剂量给药后0.5至1小时出现的平均血清峰值浓度（3.6 - 4.8μg/ml），与文献报道的相似。
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本文引用的文献
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Method of estimating relative absorption of a drug in a series of clinical studies in which blood levels are measured after single and/or multiple doses.在一系列临床研究中估计药物相对吸收的方法，这些研究中在单次和/或多次给药后测量血药浓度。
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Ann N Y Acad Sci. 1968 Jul 31;151(2):723-33. doi: 10.1111/j.1749-6632.1968.tb48255.x.
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Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes.利福平诱导的人及豚鼠肝细胞滑面内质网的变化
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Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease.利福平与异烟肼单独及联合给药于正常受试者和肝病患者的动力学。
Gut. 1972 Jan;13(1):47-53. doi: 10.1136/gut.13.1.47.
10
Metabolic study and controlled clinical trials of rifampin.利福平的代谢研究及对照临床试验。
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