由活性诱导信号分子CPG15促进树突生长。
Promotion of dendritic growth by CPG15, an activity-induced signaling molecule.
作者信息
Nedivi E, Wu G Y, Cline H T
机构信息
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
出版信息
Science. 1998 Sep 18;281(5384):1863-6. doi: 10.1126/science.281.5384.1863.
Abstract
Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. In Xenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neurons through an intercellular signaling mechanism that requires its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.
摘要
不依赖活动和依赖活动的机制协同作用来调节神经元生长，确保形成精确的突触连接。CPG15是一种受突触活动调节的蛋白质，在体内作为一种细胞表面促生长分子发挥作用。在非洲爪蟾中，CPG15增强了投射神经元的树突分支生长，对中间神经元没有影响。CPG15通过一种需要其糖基磷脂酰肌醇连接的细胞间信号传导机制控制邻近神经元的生长。CPG15可能代表了一类新的受活动调节的、膜结合的、促生长蛋白质，这类蛋白质允许对神经元结构进行精确的空间和时间控制。
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