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1
Identification of two laminin-binding fimbriae, the type 1 fimbria of Salmonella enterica serovar typhimurium and the G fimbria of Escherichia coli, as plasminogen receptors.鉴定出两种层粘连蛋白结合菌毛，即肠炎沙门氏菌鼠伤寒血清型的1型菌毛和大肠杆菌的G菌毛，作为纤溶酶原受体。
Infect Immun. 1998 Oct;66(10):4965-70. doi: 10.1128/IAI.66.10.4965-4970.1998.
2
Basement membrane carbohydrate as a target for bacterial adhesion: binding of type I fimbriae of Salmonella enterica and Escherichia coli to laminin.作为细菌黏附靶点的基底膜碳水化合物：肠炎沙门氏菌和大肠杆菌I型菌毛与层粘连蛋白的结合
Mol Microbiol. 1993 Jan;7(2):229-37. doi: 10.1111/j.1365-2958.1993.tb01114.x.
3
Enhancement of tissue plasminogen activator-catalyzed plasminogen activation by Escherichia coli S fimbriae associated with neonatal septicaemia and meningitis.
Thromb Haemost. 1991 May 6;65(5):483-6.
4
Plasminogen, absorbed by Escherichia coli expressing curli or by Salmonella enteritidis expressing thin aggregative fimbriae, can be activated by simultaneously captured tissue-type plasminogen activator (t-PA).被表达卷曲菌毛的大肠杆菌或表达细聚集菌毛的肠炎沙门氏菌吸附的纤溶酶原，可被同时捕获的组织型纤溶酶原激活剂（t-PA）激活。
Mol Microbiol. 1994 Nov;14(3):443-52. doi: 10.1111/j.1365-2958.1994.tb02179.x.
5
Plasminogen receptors. Turning Salmonella and Escherichia coli into proteolytic organisms.纤溶酶原受体。将沙门氏菌和大肠杆菌转变为蛋白水解生物。
Adv Exp Med Biol. 1997;412:185-92.
6
Bacterial plasminogen receptors: in vitro evidence for a role in degradation of the mammalian extracellular matrix.细菌纤溶酶原受体：参与哺乳动物细胞外基质降解作用的体外证据
Infect Immun. 1995 Sep;63(9):3659-64. doi: 10.1128/iai.63.9.3659-3664.1995.
7
Binding of plasminogen to Escherichia coli adhesion proteins.纤溶酶原与大肠杆菌粘附蛋白的结合。
FEBS Lett. 1989 Jul 3;250(2):437-40. doi: 10.1016/0014-5793(89)80772-0.
8
Immobilization of plasminogen on Escherichia coli flagella.纤溶酶原在大肠杆菌鞭毛上的固定化。
FEMS Microbiol Lett. 1993 Feb 1;106(3):309-14. doi: 10.1111/j.1574-6968.1993.tb05981.x.
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Regulation of macrophage receptor-bound plasmin by autoproteolysis.巨噬细胞受体结合纤溶酶的自催化调节作用。
J Biol Chem. 1994 Dec 23;269(51):32660-6.
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FimW is a negative regulator affecting type 1 fimbrial expression in Salmonella enterica serovar typhimurium.FimW是一种负调控因子，影响鼠伤寒沙门氏菌1型菌毛的表达。
J Bacteriol. 2001 Jan;183(2):435-42. doi: 10.1128/JB.183.2.435-442.2001.

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Surface Protein Dispersin of Enteroaggregative Binds Plasminogen That Is Converted Into Active Plasmin.聚集性肠杆菌的表面蛋白分散素结合可转化为活性纤溶酶的纤溶酶原。
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Everything You Always Wanted to Know About Type 1 Fimbriae, but Were Afraid to Ask.关于1型菌毛你一直想知道但却不敢问的一切。
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3
Adhesion of to Pancreatic Secretory Granule Membrane Major Glycoprotein GP2 of Human and Porcine Origin Depends on FimH Sequence Variation.[细菌]对人和猪源胰腺分泌颗粒膜主要糖蛋白GP2的黏附取决于FimH序列变异。
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Plasminogen-binding proteins as an evasion mechanism of the host's innate immunity in infectious diseases.纤溶酶原结合蛋白作为感染性疾病中宿主固有免疫逃避的机制。
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The Novel Type 1 Fimbriae FimH Receptor Calreticulin Plays a Role in Host Specificity.新型 1 型菌毛 FimH 受体钙网织蛋白在宿主特异性中发挥作用。
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Penicillin binding protein 3 of Staphylococcus aureus NCTC 8325-4 binds and activates human plasminogen.金黄色葡萄球菌NCTC 8325-4的青霉素结合蛋白3可结合并激活人纤溶酶原。
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Fructose-1,6-bisphosphate aldolase of Neisseria meningitidis binds human plasminogen via its C-terminal lysine residue.脑膜炎奈瑟菌的果糖-1,6-二磷酸醛缩酶通过其C末端赖氨酸残基与人纤溶酶原结合。
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Dancing to another tune-adhesive moonlighting proteins in bacteria.跳起别样的舞蹈——细菌中的黏着性 moonlighting 蛋白。
Biology (Basel). 2014 Mar 10;3(1):178-204. doi: 10.3390/biology3010178.
9
The Bfp60 surface adhesin is an extracellular matrix and plasminogen protein interacting in Bacteroides fragilis.Bfp60 表面黏附素是一种细胞外基质和纤溶酶原蛋白，可与脆弱拟杆菌相互作用。
Int J Med Microbiol. 2013 Dec;303(8):492-7. doi: 10.1016/j.ijmm.2013.06.007. Epub 2013 Jun 21.
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Bacterial plasminogen receptors: mediators of a multifaceted relationship.细菌纤溶酶原受体：多方面关系的介质
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本文引用的文献

1
Expression of plasminogen activator pla of Yersinia pestis enhances bacterial attachment to the mammalian extracellular matrix.鼠疫耶尔森菌纤溶酶原激活物pla的表达增强了细菌对哺乳动物细胞外基质的黏附。
Infect Immun. 1998 Dec;66(12):5755-62. doi: 10.1128/IAI.66.12.5755-5762.1998.
2
Staphylococcus aureus stimulates urokinase-type plasminogen activator expression by bovine mammary cells.
J Infect Dis. 1997 Dec;176(6):1637-40. doi: 10.1086/517345.
3
Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice.纤溶酶原对于伯氏疏螺旋体在蜱虫中的有效传播以及小鼠螺旋体血症的增强是必需的。
Cell. 1997 Jun 27;89(7):1111-9. doi: 10.1016/s0092-8674(00)80298-6.
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Plasminogen activation by invasive human pathogens.侵袭性人类病原体对纤溶酶原的激活作用。
Thromb Haemost. 1997 Jan;77(1):1-10.
5
Identification of plasminogen in Matrigel and its activation by reconstitution of this basement membrane extract.
Biotechniques. 1996 Nov;21(5):904-9. doi: 10.2144/96215rr03.
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Identification of a plasminogen-binding motif in PAM, a bacterial surface protein.
Mol Microbiol. 1995 Nov;18(3):569-78. doi: 10.1111/j.1365-2958.1995.mmi_18030569.x.
7
The GafD protein of the G (F17) fimbrial complex confers adhesiveness of Escherichia coli to laminin.G（F17）菌毛复合体的GafD蛋白赋予大肠杆菌对层粘连蛋白的黏附性。
Infect Immun. 1996 Jul;64(7):2857-60. doi: 10.1128/iai.64.7.2857-2860.1996.
8
Bacterial collagenases and collagen-degrading enzymes and their potential role in human disease.细菌胶原酶和胶原蛋白降解酶及其在人类疾病中的潜在作用。
Infect Immun. 1996 Jun;64(6):1885-91. doi: 10.1128/iai.64.6.1885-1891.1996.
9
Interaction of Haemophilus influenzae with the mammalian extracellular matrix.
J Infect Dis. 1996 May;173(5):1137-47. doi: 10.1093/infdis/173.5.1137.
10
Immobilization of plasminogen on Escherichia coli flagella.纤溶酶原在大肠杆菌鞭毛上的固定化。
FEMS Microbiol Lett. 1993 Feb 1;106(3):309-14. doi: 10.1111/j.1574-6968.1993.tb05981.x.

鉴定出两种层粘连蛋白结合菌毛，即肠炎沙门氏菌鼠伤寒血清型的1型菌毛和大肠杆菌的G菌毛，作为纤溶酶原受体。

Identification of two laminin-binding fimbriae, the type 1 fimbria of Salmonella enterica serovar typhimurium and the G fimbria of Escherichia coli, as plasminogen receptors.

作者信息

Kukkonen M, Saarela S, Lähteenmäki K, Hynönen U, Westerlund-Wikström B, Rhen M, Korhonen T K

机构信息

Division of General Microbiology, Department of Biosciences, FIN-00014 University of Helsinki, Finland.

出版信息

Infect Immun. 1998 Oct;66(10):4965-70. doi: 10.1128/IAI.66.10.4965-4970.1998.

DOI:10.1128/IAI.66.10.4965-4970.1998
PMID:9746604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108615/
Abstract

Escherichia coli strains carrying recombinant plasmids encoding either the type 1 fimbria of Salmonella enterica serovar Typhimurium or the G fimbria of E. coli exhibited binding of human 125I-Glu-plasminogen and enhanced the tissue-type plasminogen activator-catalyzed conversion of plasminogen to plasmin. Purified type 1 or G fimbriae similarly bound plasminogen and enhanced its activation. The binding of plasminogen did not involve the characteristic carbohydrate-binding property of the fimbriae but was inhibited at low concentrations by the lysine analog epsilon-aminocaproic acid. Because these fimbrial types bind to laminin of basement membranes (M. Kukkonen et al., Mol. Microbiol. 7:229-237, 1993; S. Saarela et al., Infect. Immun. 64:2857-2860, 1996), the results demonstrate a structural unity in the creation and targeting of bacterium-bound proteolytic plasmin activity to basement membranes.

摘要

携带编码肠炎沙门氏菌鼠伤寒血清型1型菌毛或大肠杆菌G菌毛的重组质粒的大肠杆菌菌株表现出人125I-谷氨酸-纤溶酶原的结合，并增强了组织型纤溶酶原激活剂催化的纤溶酶原向纤溶酶的转化。纯化的1型或G菌毛同样结合纤溶酶原并增强其激活。纤溶酶原的结合不涉及菌毛的特征性碳水化合物结合特性，但在低浓度下被赖氨酸类似物ε-氨基己酸抑制。由于这些菌毛类型与基底膜的层粘连蛋白结合（M. Kukkonen等人，《分子微生物学》7:229-237，1993；S. Saarela等人，《感染与免疫》64:2857-2860，1996），结果表明在细菌结合的蛋白水解纤溶酶活性向基底膜的产生和靶向方面存在结构统一性。