Barbosa Santos E G, Marzochi M C, Conceição N F, Brito C M, Barroso J A, Pacheco R S
Departamento de Ciências Biológicas, Escola Nacional de Saúde Pública, FIOCRUZ, Rio de Janeiro, Brazil.
Parasite. 1998 Jun;5(2):175-80. doi: 10.1051/parasite/1998052175.
Twenty five adult dogs of three municipalities of the State of Rio de Janeiro, Brazil, that had been naturally infected by L. (V) braziliensis were treated with N-methylglucamine antimonate (Glucantime). Nine of the animals (36.0%) presented ulcerated skin lesions, twelve (48.0%) had mucosal lesions and four (16.0%) had multiple lesions. In some cases the mucosal lesions were associated to skin lesions. A dose of 85 mg SbV+ or 1 ml of the drug was intralesionally administered to the dogs. The animals were divided into three groups according to the amount of necessary doses (between one and three) for the complete healing of the lesions. The dogs were observed for six months after the third group received the last dose. Within this period two animals perished. Serial antibody evaluation through IFAT has shown that in 14 samples (63.3%) the titers have remained unaltered, in four of them (16%) there has been a decrease in two titers and in five of them (21%) serology was negative. Nineteen of the dogs (86.6%) had their lesions completely healed. The authors suggest intralesional therapy be the first choice of treatment of canine tegumentary leishmaniasis due to its effectiveness.
巴西里约热内卢州三个市的25只自然感染巴西利什曼原虫（Viannia亚属）的成年犬，接受了葡甲胺锑酸盐（葡糖胺锑）治疗。其中9只动物（36.0%）出现皮肤溃疡病变，12只（48.0%）有黏膜病变，4只（16.0%）有多处病变。在某些情况下，黏膜病变与皮肤病变相关。给犬只病变内注射85mg SbV⁺或1ml药物。根据病变完全愈合所需剂量（1至3剂）将动物分为三组。在第三组接受最后一剂后，对犬只观察了6个月。在此期间，有2只动物死亡。通过间接荧光抗体试验进行的系列抗体评估表明，14份样本（63.3%）的滴度保持不变，其中4份（16%）的两个滴度有所下降，5份（21%）血清学呈阴性。19只犬（86.6%）的病变完全愈合。作者认为，由于病变内治疗有效，应作为犬皮肤利什曼病的首选治疗方法。
