Koomsiri Wilaiwan, Inahashi Yuki, Kimura Tōru, Shiomi Kazuro, Takahashi Yōko, Ōmura Satoshi, Thamchaipenet Arinthip, Nakashima Takuji
Department of Genetics, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
J Antibiot (Tokyo). 2017 Dec;70(12):1142-1145. doi: 10.1038/ja.2017.113. Epub 2017 Sep 27.
Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of 'Streptomyces subflavus subsp. irumaensis' AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.
通过物理化学筛选方法，从“浅黄链霉菌入间亚种”AM - 3603的培养液中鉴定出双恶唑霉素（1）、恶唑霉素A2（2）和恶唑霉素A（3）。化合物2是化合物3在β - 内酯环处的水解类似物，化合物1是化合物2的一种新型二聚类似物。与化合物3相比，化合物1和2表现出较弱的抗菌活性和细胞毒性，这可能是由于缺乏β - 内酯环所致。
