Yang W, Jennison B L, Omaye S T
Department of Nutrition and the Environmental Sciences and Health Graduate Program, University of Nevada, Reno 89557, USA.
J Toxicol Environ Health A. 1998 Oct 9;55(3):185-96. doi: 10.1080/009841098158485.
Recent research suggests that some cases of cardiovascular mortality may be related to carbon monoxide (CO) air pollution. Clinically based studies indicate the adverse effects of CO on the cardiopulmonary system. However, little attention has been paid to the question of hospital admissions for cardiovascular illness caused by ambient CO levels. The present study assesses the association between hospital admissions for cardiovascular system illnesses and the ambient levels of CO in the Reno-Sparks, NV, area over a 6-yr period (1989-1994). Daily admissions to all three hospitals in the region and daily ambient concentrations of CO, monitored at five sites, were included. There were 32,705 total cardiovascular (CV) admissions, including 13,108 with the diagnosis of ischemic heart disease (IHD) during the study period. The average daily 1-h maximum level of CO was 3.09 ppm. After adjusting for day-of-the-week and seasonal effects and controlling for the effects of autocorrelation errors, both weighted least squares (WLS) and autoregressive integrated moving average (ARIMA) methods showed consistently positive relationships between the ambient CO level and different groups of cardiovascular admissions, although the male gender and age older than 60 groups tended to be most affected. Data suggest a positive correlation between ambient CO levels and hospital admissions for CV diseases.
最近的研究表明，某些心血管疾病死亡病例可能与一氧化碳（CO）空气污染有关。基于临床的研究表明了CO对心肺系统的不良影响。然而，对于环境中CO水平导致心血管疾病住院的问题却很少有人关注。本研究评估了内华达州里诺 - 斯帕克斯地区6年期间（1989 - 1994年）心血管系统疾病住院情况与环境CO水平之间的关联。纳入了该地区所有三家医院的每日住院人数以及在五个地点监测到的CO每日环境浓度。在研究期间，心血管（CV）住院总数为32,705例，其中13,108例诊断为缺血性心脏病（IHD）。CO的每日1小时最高平均水平为3.09 ppm。在对一周中的日期和季节效应进行调整并控制自相关误差的影响后，加权最小二乘法（WLS）和自回归积分移动平均法（ARIMA）均显示环境CO水平与不同组别的心血管住院之间始终存在正相关关系，尽管男性和60岁以上年龄组受影响的程度往往最大。数据表明环境CO水平与CV疾病住院之间存在正相关。
