Kropp B P
Department of Urology, Children's Hospital of Oklahoma, University of Oklahoma Health Science Center, Oklahoma City, USA.
World J Urol. 1998;16(4):262-7. doi: 10.1007/s003450050064.
The need to find an alternative to the use of bowel for urinary reconstruction has renewed research interests involving bladder regeneration. Historically, alloplastic and biodegradable materials have demonstrated bladder regeneration; however, high complication rates and unreliable regenerative results have prevented any of these materials from being used clinically. Small-intestinal submucosa (SIS) is an acellular, nonimmunogenic, biodegradable, xenogeneic, collagen-based material that is derived from the submucosa layer of porcine small intestine. SIS has demonstrated regenerative capacities in multiple organ systems, including the aorta, vena cava, ligaments, tendons, abdominal wall, and skin. SIS has also demonstrated long-term reliable regenerative results in the rat and canine bladder-augmentation models. This article reviews the preclinical studies involving the use of SIS for bladder augmentation.
寻找用于尿路重建的肠道替代物的需求重新激发了对膀胱再生的研究兴趣。从历史上看，异体塑料和可生物降解材料已证明可实现膀胱再生；然而，高并发症发生率和不可靠的再生结果阻碍了这些材料中的任何一种在临床上的使用。小肠黏膜下层（SIS）是一种无细胞、无免疫原性、可生物降解、异种的、基于胶原蛋白的材料，它源自猪小肠的黏膜下层。SIS已在包括主动脉、腔静脉、韧带、肌腱、腹壁和皮肤在内的多个器官系统中展现出再生能力。SIS在大鼠和犬膀胱扩大模型中也展现出长期可靠的再生结果。本文综述了涉及使用SIS进行膀胱扩大的临床前研究。
