Kropp B P, Rippy M K, Badylak S F, Adams M C, Keating M A, Rink R C, Thor K B
Department of Urology, Indiana University Medical Center, Indianapolis, USA.
J Urol. 1996 Jun;155(6):2098-104. doi: 10.1016/s0022-5347(01)66117-2.
To evaluate small intestinal submucosa (SIS) as a possible bladder augmentation material.
Nineteen male dogs underwent 35 to 45% partial cystectomy with immediate augmentation with SIS grafts. All dogs were evaluated pre- and postoperatively with blood chemistries, urine cultures, intravenous urograms, cystograms and cystometrograms. Postoperatively (1 to 15 months), bladders were examined with routine histology and image analysis.
All dogs survived their intended survival period without morbidity. All results were normal. Histologically, all 3 layers (mucosa, smooth muscle, serosa) of the normal bladder showed evidence of regeneration.
Small intestinal submucosa acts as a scaffold for bladder augmentation through regeneration and could be a potential option for bladder reconstruction.
评估小肠黏膜下层（SIS）作为一种可能的膀胱扩大材料。
19只雄性犬接受了35%至45%的部分膀胱切除术，并立即用SIS移植物进行扩大。所有犬在术前和术后均进行了血液化学检查、尿培养、静脉肾盂造影、膀胱造影和膀胱测压。术后（1至15个月），对膀胱进行常规组织学检查和图像分析。
所有犬均存活至预期生存期，无发病情况。所有结果均正常。组织学上，正常膀胱的所有三层（黏膜、平滑肌、浆膜）均显示有再生迹象。
小肠黏膜下层通过再生为膀胱扩大提供支架，可能是膀胱重建的一个潜在选择。
