Zhao Pan, Li Xiang, Fang Qin, Wang Fanglin, Ao Qiang, Wang Xiaohong, Tian Xiaohong, Tong Hao, Bai Shuling, Fan Jun
Department of Tissue Engineering, School of Fundamental Sciences, China Medical University, 77 Puhe Avenue, Shenbei New District, Shenyang 110122, China.
Department of Cell Biology, School of Life Sciences, China Medical University, 77 Puhe Avenue, Shenbei New District, Shenyang 110122, China.
Regen Biomater. 2020 Aug;7(4):339-348. doi: 10.1093/rb/rbaa014. Epub 2020 May 18.
With the development of tissue engineering, the required biomaterials need to have the ability to promote cell adhesion and proliferation and . Especially, surface modification of the scaffold material has a great influence on biocompatibility and functionality of materials. The small intestine submucosa (SIS) is an extracellular matrix isolated from the submucosal layer of porcine jejunum, which has good tissue mechanical properties and regenerative activity, and is suitable for cell adhesion, proliferation and differentiation. In recent years, SIS is widely used in different areas of tissue reconstruction, such as blood vessels, bone, cartilage, bladder and ureter, etc. This paper discusses the main methods for surface modification of SIS to improve and optimize the performance of SIS bioscaffolds, including functional group bonding, protein adsorption, mineral coating, topography and formatting modification and drug combination. In addition, the reasonable combination of these methods also offers great improvement on SIS surface modification. This article makes a shallow review of the surface modification of SIS and its application in tissue engineering.
随着组织工程的发展，所需的生物材料需要具备促进细胞黏附和增殖的能力。特别是，支架材料的表面改性对材料的生物相容性和功能有很大影响。小肠黏膜下层（SIS）是从猪空肠黏膜下层分离出的细胞外基质，具有良好的组织力学性能和再生活性，适用于细胞黏附、增殖和分化。近年来，SIS广泛应用于组织重建的不同领域，如血管、骨骼、软骨、膀胱和输尿管等。本文讨论了SIS表面改性以改善和优化SIS生物支架性能的主要方法，包括官能团键合、蛋白质吸附、矿物涂层、形貌和形态改性以及药物结合。此外，这些方法的合理组合也为SIS表面改性带来了很大的改进。本文对SIS的表面改性及其在组织工程中的应用进行了简要综述。
