Kropp B P, Sawyer B D, Shannon H E, Rippy M K, Badylak S F, Adams M C, Keating M A, Rink R C, Thor K B
Department of Urology, Riley Children's Hospital, Indiana University School of Medicine, Lafayette, USA.
J Urol. 1996 Aug;156(2 Pt 2):599-607. doi: 10.1097/00005392-199608001-00008.
We characterized small intestinal submucosa regenerated canine bladder.
We subjected 15-month small intestinal submucosa regenerated canine bladder strips to in vitro muscle bath compliance, contractility testing and immunohistochemical staining.
Compliance studies demonstrated no significant difference between small intestinal submucosa regenerated and control bladders, which were 30-fold more compliant than native small intestinal submucosal graft material. Contractility studies demonstrated contractile responses and innervation similar to those of normal canine bladder. Afferent nerves were demonstrated through immunohistochemical techniques.
These characteristics further support the regenerative capacity of small intestinal submucosa and its potential use as a bladder augmentation material.
我们对小肠黏膜下层再生犬膀胱进行了特征描述。
我们对15个月大的小肠黏膜下层再生犬膀胱条进行了体外肌肉浴顺应性、收缩性测试及免疫组织化学染色。
顺应性研究表明，小肠黏膜下层再生膀胱与对照膀胱之间无显著差异，二者的顺应性比天然小肠黏膜下层移植材料高30倍。收缩性研究表明，其收缩反应和神经支配与正常犬膀胱相似。通过免疫组织化学技术证实了传入神经的存在。
这些特征进一步支持了小肠黏膜下层的再生能力及其作为膀胱扩大材料的潜在用途。
