Von Essen S G, Scheppers L A, Robbins R A, Donham K J
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-5300, USA.
J Toxicol Clin Toxicol. 1998;36(6):557-65. doi: 10.3109/15563659809028049.
To further define the asthma-like syndrome seen in swine confinement workers.
A cross-sectional study was performed at a swine confinement facility in rural Nebraska and at the University of Nebraska Medical Center, Omaha, Nebraska.
24 swine confinement workers and 14 urban normal control subjects. All subjects completed a questionnaire concerning respiratory complaints. We performed hypertonic saline challenges on the swine confinement workers and control subjects in order to induce expectoration of sputum. Cell counts and cell differentials were determined in the induced sputum samples. Nasal, mean, and peak exhaled nitric oxide was measured in both groups. Spirometry was also done.
Swine confinement workers were significantly more likely to report wheezing, cough, and sinusitis symptoms than controls (p = .003). Macrophages were significantly elevated in the induced sputum samples of the swine confinement workers vs the control subjects (0.59 macrophages/mL +/- 0.1 SEM vs 0.36 +/- .16; p = .006), while there was no difference in numbers of neutrophils. No eosinophils were observed. A small elevation in mean exhaled nitric oxide was seen in the swine confinement workers compared to normal controls (11.7 ppb +/- 0.6 SEM vs 10.2 +/- 1.6; p = 0.023). Spirometry values did not differ statistically between swine confinement workers and the control group.
Swine confinement workers have signs and symptoms of lower respiratory tract inflammation when studied using induced sputum and exhaled nitric oxide. Findings in the swine confinement workers differ from those in asthmatics and chronic bronchitis.
进一步明确在封闭式养猪场工作的人员中出现的类似哮喘的综合征。
在内布拉斯加州农村的一个封闭式养猪场以及内布拉斯加州奥马哈市的内布拉斯加大学医学中心进行了一项横断面研究。
24名封闭式养猪场工作人员和14名城市正常对照者。所有受试者均完成了一份关于呼吸道症状的问卷。我们对封闭式养猪场工作人员和对照者进行了高渗盐水激发试验，以诱导痰液咳出。对诱导痰液样本进行细胞计数和细胞分类。两组均测量了鼻腔、平均及呼出一氧化氮峰值。还进行了肺功能测定。
与对照组相比，封闭式养猪场工作人员更易出现喘息、咳嗽和鼻窦炎症状（p = 0.003）。与对照者相比，封闭式养猪场工作人员诱导痰液样本中的巨噬细胞显著升高（0.59个巨噬细胞/毫升±0.1标准误 vs 0.36±0.16；p = 0.006），而中性粒细胞数量无差异。未观察到嗜酸性粒细胞。与正常对照组相比，封闭式养猪场工作人员呼出一氧化氮平均值略有升高（11.7 ppb±0.6标准误 vs 10.2±1.6；p = 0.023）。封闭式养猪场工作人员和对照组的肺功能测定值在统计学上无差异。
使用诱导痰液和呼出一氧化氮进行研究时，封闭式养猪场工作人员存在下呼吸道炎症的体征和症状。封闭式养猪场工作人员的研究结果与哮喘患者和慢性支气管炎患者不同。
