Nomiyama K, Tsuji H, Ikeda K, Kawatoko T, Kashiwagi S, Nakamura S, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Fukuoka Igaku Zasshi. 1998 Aug;89(8):232-7.
Hepatitis C virus antibody (anti-HCV) was studied in 267 patients undergoing maintenance hemodialysis using an anti-HCV enzyme-linked immunosorbent assay. Furthermore, both hepatitis B virus core antibody (anti-HBc) and human T cell leukemia virus type 1 antibody (anti-HTLV-1) were determined in these patients to compare their prevalence rates. Seventy one patients (27%) had positive anti-HCV, 134 patients (50%) positive anti-HBc and 40 patients (15%) positive anti-HTVL-1. Among the 183 patients who had received blood transfusion, the prevalence of these antibodies was 34% for anti-HCV, 56% for anti-HBc and 17% for anti-HTLV-1, respectively. A significance between those with and without blood transfusion was recognized for anti-HCV (p < 0.001) and anti-HBc (p < 0.01). Of 56 patients who had received hemodialysis for over 15 years, the positive antibody was found in 63% for anti-HCV (p < 0.001), 73% for anti-HBc (p < 0.001) and 25% for anti-HTLV-1 (p < 0.05), which was significantly higher than that of patients receiving a less than 15 years hemodialysis. The prevalence rates of anti-HCV and anti-HTLV-1 did not increase with age, while that of anti-HBc increased. These findings suggest that blood transfusions during hemodialysis play a very important role in the infection of hepatitis C virus.
采用抗丙型肝炎病毒酶联免疫吸附试验，对267例维持性血液透析患者的丙型肝炎病毒抗体（抗-HCV）进行了研究。此外，还对这些患者的乙型肝炎病毒核心抗体（抗-HBc）和人类T细胞白血病病毒1型抗体（抗-HTLV-1）进行了检测，以比较它们的流行率。71例患者（27%）抗-HCV呈阳性，134例患者（50%）抗-HBc呈阳性，40例患者（15%）抗-HTVL-1呈阳性。在183例接受过输血的患者中，这些抗体的流行率分别为抗-HCV 34%、抗-HBc 56%和抗-HTLV-1 17%。抗-HCV（p<0.001）和抗-HBc（p<0.01）在输血患者和未输血患者之间存在显著差异。在56例接受血液透析超过15年的患者中，抗-HCV阳性率为63%（p<0.001），抗-HBc阳性率为73%（p<0.001），抗-HTLV-1阳性率为25%（p<0.05），均显著高于透析时间不足15年的患者。抗-HCV和抗-HTLV-1的流行率不随年龄增长而增加，而抗-HBc的流行率则增加。这些发现表明，血液透析期间的输血在丙型肝炎病毒感染中起着非常重要的作用。
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