在长期随访中，人类细小病毒B19感染之后并未出现炎性关节疾病。一项对54例患者的回顾性研究。
Human parvovirus B19 infection is not followed by inflammatory joint disease during long term follow-up. A retrospective study of 54 patients.
作者信息
Speyer I, Breedveld F C, Dijkmans B A
机构信息
Department of Rheumatology, Leiden University Medical Center, The Netherlands.
出版信息
Clin Exp Rheumatol. 1998 Sep-Oct;16(5):576-8.
OBJECTIVE
To investigate whether recent human parvovirus B19 (B19) infection provokes inflammatory arthritis, we assessed the outcome of 54 patients with recent B19 infection who were referred to the Department of Rheumatology.
METHODS
Consecutive patients referred between 1985 and 1995 and found to have a recent B19 infection were studied retrospectively by sending a questionnaire and, if necessary, by physical examination.
RESULTS
In the acute phase of B19 infection, all patients had arthralgia and many also complained of myalgia and malaise. Arthritis was found in 61% of the patients, skin rash in 72% and fever in 64%. Except for the arthralgia and malaise, most of the symptoms resolved rapidly. After a mean followup of 5 years (SD 2.9 yrs.) none of the patients reported persistence of joint swelling or restricted motion.
CONCLUSION
None of the 54 patients with recent B19 infection developed chronic arthritis.
目的
为了研究近期人类细小病毒B19（B19）感染是否会引发炎性关节炎，我们评估了54例近期感染B19且被转诊至风湿病科的患者的病情转归。
方法
对1985年至1995年间连续转诊且被发现近期感染B19的患者进行回顾性研究，通过发放问卷进行调查，必要时进行体格检查。
结果
在B19感染的急性期，所有患者均有关节痛，许多患者还主诉有肌痛和不适。61%的患者出现关节炎，72%出现皮疹，64%出现发热。除关节痛和不适外，大多数症状迅速缓解。平均随访5年（标准差2.9年）后，没有患者报告有关节肿胀持续或活动受限的情况。
结论
54例近期感染B19的患者均未发展为慢性关节炎。
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