Girgis N, Sultan Y, Frenck R W, El-Gendy A, Farid Z, Mateczun A
Clinical Investigations Branch, Naval Medical Research Unit No. 3, FPO AE 09835-0007, USA.
Pediatr Infect Dis J. 1998 Sep;17(9):816-9. doi: 10.1097/00006454-199809000-00013.
To evaluate the efficacy and safety of azithromycin compared with rifampin for eradication of nasopharyngeal carriage of Neisseria meningitidis
Pharyngeal swabs were obtained from 500 students attending nursing school in Cairo, Egypt, to determine the colonization rate with N. meningitidis. Colonized individuals were randomized to receive azithromycin (500 mg once) or rifampin (600 mg twice daily for four doses). Subjects were then recultured 1 and 2 weeks posttreatment to determine the effectiveness of the antibiotic therapy for eradication of meningococcal nasopharyngeal colonization.
Individuals treated with azithromycin had a 93% eradication rate at 1 and 2 weeks posttreatment comparable with 95 and 91%, respectively, for rifampin. No significant side effects were reported by any subjects treated with either antibiotic.
Azithromycin is effective in the eradication of N. meningitidis from the nasopharynx of asymptomatic colonized individuals and deserves further evaluation for use as prophylaxis against N. meningitidis.
评估阿奇霉素与利福平在消除脑膜炎奈瑟菌鼻咽部携带方面的疗效和安全性。
从埃及开罗一所护理学校的500名学生中获取咽拭子，以确定脑膜炎奈瑟菌的定植率。将定植者随机分为接受阿奇霉素（500毫克单次服用）或利福平（600毫克每日两次，共四剂）治疗。然后在治疗后1周和2周对受试者进行再次培养，以确定抗生素治疗消除脑膜炎奈瑟菌鼻咽部定植的有效性。
接受阿奇霉素治疗的个体在治疗后1周和2周的根除率分别为93%，利福平治疗的相应根除率分别为95%和91%。使用这两种抗生素治疗的任何受试者均未报告明显副作用。
阿奇霉素在消除无症状定植个体鼻咽部的脑膜炎奈瑟菌方面有效，值得进一步评估作为预防脑膜炎奈瑟菌的用药。
