Yamazumi T, Kuroda T, Ohata T, Obana Y, Furuta I
Department of Clinical Pathology, Kinki University School of Medicine.
Kansenshogaku Zasshi. 1998 Aug;72(8):813-9. doi: 10.11150/kansenshogakuzasshi1970.72.813.
In this study we investigated the antifungal susceptibility of 285 strains of Candida albicans isolates at Kinki University Hospital from March 1995 to December 1996. The antifungal agents tested were fluconazole, miconazole, intraconazole, amphotericin B and flucytosine. The susceptibility testing were performed according to the broth microdilution method standardized by National Committee for Clinical Laboratory Standards (M27-T). Most isolates of C. albicans showed relatively a low MIC value and the MIC90S were calculated at 1 microgram/ml; fluconazole, 0.125 microgram/mg; miconazole, 0.06 microgram/ml; itraconazole, 1 microgram/ml; amphotericin B, 0.25 microgram/ml; flucytosine. There was only one strain that showed high resistance against fluconazole and it showed cross-resistance against miconazole and itraconazole. There were two flucytosine resistant strains. The MICs of amphotericin B were tightly clustered and resistant strain were not observed.
在本研究中，我们调查了1995年3月至1996年12月期间在近畿大学医院分离出的285株白色念珠菌的抗真菌药敏性。所测试的抗真菌药物为氟康唑、咪康唑、伊曲康唑、两性霉素B和氟胞嘧啶。药敏试验按照美国国家临床实验室标准委员会（M27-T）标准化的肉汤微量稀释法进行。大多数白色念珠菌分离株显示出相对较低的最低抑菌浓度（MIC）值，MIC90分别计算为：氟康唑1微克/毫升、咪康唑0.125微克/毫克、伊曲康唑1微克/毫升、两性霉素B 0.25微克/毫升、氟胞嘧啶。只有一株对氟康唑显示出高耐药性，并且对咪康唑和伊曲康唑表现出交叉耐药性。有两株对氟胞嘧啶耐药的菌株。两性霉素B的MIC值紧密聚集，未观察到耐药菌株。
