Czlonkowska A, Milewski B
J Neurol Sci. 1976 Oct;29(2-4):411-21. doi: 10.1016/0022-510x(76)90188-x.
In 19 patients with Wilson's disease we found an increased humoral immune response, i.e. a higher level of IgG and IgM, a higher titre of antibodies against Kunin's CA antigen and a depressed cell-mediated immunity i.e. a lower response to DNCB and E. coli in skin tests, lower lymphocyte transformation when stimulated by Con A, PPD, Candida albicans and streptokinase and a lower production of macrophage migration inhibition factor. The changes observed in the group of patients with liver cirrhosis caused by other facotrs than Wilson's disease were similar but less pronounced. We also found that leukocytes of patients with Wilson's disease have an impaired bactericidal activity and that copper ions have an inhibitory effect on some tests for cell-mediated immunity. It seems probable that immunological abnormalities in Wilson's disease are caused by liver cirrhosis but we cannot exclude an inhibitory effect of copper ions upon the immune response and an associated effect upon leukocyte metabolism.
在19例威尔逊病患者中，我们发现其体液免疫反应增强，即IgG和IgM水平升高、抗库宁CA抗原的抗体滴度升高，而细胞介导免疫功能低下，即皮肤试验中对二硝基氯苯和大肠杆菌的反应较低、在刀豆蛋白A、结核菌素纯蛋白衍生物、白色念珠菌和链激酶刺激下淋巴细胞转化率较低以及巨噬细胞移动抑制因子产生减少。在由威尔逊病以外的其他因素引起肝硬化的患者组中观察到的变化相似，但不太明显。我们还发现，威尔逊病患者的白细胞杀菌活性受损，并且铜离子对某些细胞介导免疫试验有抑制作用。威尔逊病中的免疫异常似乎很可能是由肝硬化引起的，但我们不能排除铜离子对免疫反应的抑制作用以及对白细胞代谢的相关影响。
