免疫功能正常宿主中亨氏巴尔通体感染的小鼠模型。
Murine model of Bartonella henselae infection in the immunocompetent host.
作者信息
Regnath T, Mielke M E, Arvand M, Hahn H
机构信息
Institute of Infectious Diseases, University Hospital Benjamin Franklin, Free University of Berlin, 12203 Berlin, Germany.
出版信息
Infect Immun. 1998 Nov;66(11):5534-6. doi: 10.1128/IAI.66.11.5534-5536.1998.
Abstract
Bartonella henselae is an emerging pathogen causing cat scratch disease, bacillary angiomatosis, and peliosis hepatis. Progress in understanding the pathogenesis of and the immune response to these infections has been limited by the lack of an animal model. Following intraperitoneal infection of C57BL/6 mice with B. henselae, organs were cleared of cultivatable bacteria within 6 days. In contrast, B. henselae DNA could be detected in liver tissue for at least 3 months. Liver tissue showed granulomatous inflammation reaching its highest degree of intensity during the fourth week of infection and resolving within 12 weeks postinfection. This mouse model is applicable to the study of the pathogenesis of B. henselae and the immune response to this pathogen in the immunocompetent host.
摘要
汉赛巴尔通体是一种新出现的病原体，可引起猫抓病、杆菌性血管瘤病和肝紫癜。由于缺乏动物模型，在理解这些感染的发病机制和免疫反应方面进展有限。用汉赛巴尔通体腹腔感染C57BL/6小鼠后，6天内各器官中的可培养细菌被清除。相比之下，在肝组织中至少3个月都能检测到汉赛巴尔通体DNA。肝组织呈现肉芽肿性炎症，在感染后第四周达到强度最高程度，并在感染后12周内消退。该小鼠模型适用于研究免疫功能正常宿主中汉赛巴尔通体的发病机制以及对该病原体的免疫反应。
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本文引用的文献
1
Pillars article: cellular resistance to infection. J. Exp. Med. 1962. 116: 381-406.支柱文章：细胞对感染的抵抗力。《实验医学杂志》1962年。第116卷：381 - 406页。
J Immunol. 2014 Oct 1;193(7):3185-221.
2
Current knowledge of Bartonella species.巴尔通体属物种的现有知识。
Eur J Clin Microbiol Infect Dis. 1997 Jul;16(7):487-506. doi: 10.1007/BF01708232.
3
Molecular diagnosis of cat scratch disease: a two-step approach.猫抓病的分子诊断：一种两步法。
J Clin Microbiol. 1997 Aug;35(8):1924-30. doi: 10.1128/jcm.35.8.1924-1930.1997.
4
Experimental infection of young specific pathogen-free cats with Bartonella henselae.用汉赛巴尔通体对幼年无特定病原体猫进行实验性感染。
J Infect Dis. 1997 Jul;176(1):206-16. doi: 10.1086/514026.
5
6
L3T4(CD4)-, Lyt-2(CD8)- and Mac-1(CD11b)-phenotypic leukocytes in murine cryptococcal meningoencephalitis.鼠隐球菌性脑膜脑炎中L3T4（CD4）-、Lyt-2（CD8）-和Mac-1（CD11b）表型的白细胞
Mycopathologia. 1995 Sep;131(3):159-66. doi: 10.1007/BF01102895.
7
Cat scratch disease in Connecticut. Epidemiology, risk factors, and evaluation of a new diagnostic test.康涅狄格州的猫抓病。流行病学、风险因素及一种新诊断测试的评估
N Engl J Med. 1993 Jul 1;329(1):8-13. doi: 10.1056/NEJM199307013290102.
8
Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease.汉赛巴通体腺炎综合征提示猫抓病。
Ann Intern Med. 1993 Mar 1;118(5):331-6. doi: 10.7326/0003-4819-118-5-199303010-00002.
9
Development and evaluation of a blood-free medium for determining growth curves and optimizing growth of Rochalimaea henselae.用于确定汉赛巴尔通体生长曲线和优化其生长的无血培养基的研发与评估
J Clin Microbiol. 1993 Jul;31(7):1882-5. doi: 10.1128/jcm.31.7.1882-1885.1993.
10
Cat scratch disease in the United States: an analysis of three national databases.美国的猫抓病：对三个国家数据库的分析
Am J Public Health. 1993 Dec;83(12):1707-11. doi: 10.2105/ajph.83.12.1707.
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