Regnath T, Mielke M E, Arvand M, Hahn H
Institute of Infectious Diseases, University Hospital Benjamin Franklin, Free University of Berlin, 12203 Berlin, Germany.
Infect Immun. 1998 Nov;66(11):5534-6. doi: 10.1128/IAI.66.11.5534-5536.1998.
Bartonella henselae is an emerging pathogen causing cat scratch disease, bacillary angiomatosis, and peliosis hepatis. Progress in understanding the pathogenesis of and the immune response to these infections has been limited by the lack of an animal model. Following intraperitoneal infection of C57BL/6 mice with B. henselae, organs were cleared of cultivatable bacteria within 6 days. In contrast, B. henselae DNA could be detected in liver tissue for at least 3 months. Liver tissue showed granulomatous inflammation reaching its highest degree of intensity during the fourth week of infection and resolving within 12 weeks postinfection. This mouse model is applicable to the study of the pathogenesis of B. henselae and the immune response to this pathogen in the immunocompetent host.
汉赛巴尔通体是一种新出现的病原体，可引起猫抓病、杆菌性血管瘤病和肝紫癜。由于缺乏动物模型，在理解这些感染的发病机制和免疫反应方面进展有限。用汉赛巴尔通体腹腔感染C57BL/6小鼠后，6天内各器官中的可培养细菌被清除。相比之下，在肝组织中至少3个月都能检测到汉赛巴尔通体DNA。肝组织呈现肉芽肿性炎症，在感染后第四周达到强度最高程度，并在感染后12周内消退。该小鼠模型适用于研究免疫功能正常宿主中汉赛巴尔通体的发病机制以及对该病原体的免疫反应。
