Krstev S, Baris D, Stewart P A, Hayes R B, Blair A, Dosemeci M
Institute of Occupational and Radiological Health, Dr. Dragomir Karajovic, Belgrade, Yugoslavia.
Am J Ind Med. 1998 Nov;34(5):413-20. doi: 10.1002/(sici)1097-0274(199811)34:5<413::aid-ajim1>3.0.co;2-r.
Current knowledge of the etiology of prostate cancer is limited. Numerous studies have suggested that certain occupations and industries may be associated with the occurrence of prostate cancer. Information on occupation and industry on death certificates from 24 states gathered from 1984 to 1993 was used in case control study on prostate cancer. A total of 60,878 men with prostate cancer as underlying cause of death was selected and matched with controls who died of all other causes except cancer. Similar to the findings of our parallel large case control study of prostate cancer, we observed excess risks in some white-collar occupations, such as administrators, managers, teachers, engineers, and sales occupations. However, some blue-collar occupations, such as power plant operators and stationary engineers, brickmasons, machinery maintenance workers, airplane pilots, longshoreman, railroad industry workers, and other occupations with potential exposure to PAH also showed risk of excess prostate cancer. Risk was significantly decreased for blue-collar occupations, including farm workers, commercial fishermen, mechanics and repairers, structural metal workers, mining, printing, winding, dry cleaning, textile machine operators, cooks, bakers, and bartenders. Although we observed excess risks of prostate cancer among some low socioeconomic status (SES) occupations, the overall results suggest that the effects of higher SES cannot be ruled out in associations between occupational factors and the risk of prostate cancer.
目前对前列腺癌病因的了解有限。大量研究表明，某些职业和行业可能与前列腺癌的发生有关。在一项前列腺癌病例对照研究中，使用了1984年至1993年从24个州收集的死亡证明上的职业和行业信息。总共选择了60878名以前列腺癌为根本死因的男性，并与死于除癌症以外所有其他原因的对照组进行匹配。与我们平行的大型前列腺癌病例对照研究结果相似，我们观察到一些白领职业存在额外风险，如行政人员、经理、教师、工程师和销售职业。然而，一些蓝领职业，如发电厂操作员和固定工程师、砖瓦匠、机械维修工人、飞机驾驶员、码头工人、铁路行业工人以及其他可能接触多环芳烃的职业，也显示出前列腺癌风险增加。包括农场工人、商业渔民、机械师和修理工、结构金属工人、采矿工人、印刷工人、绕组工人、干洗工人、纺织机器操作员、厨师、面包师和酒保在内的蓝领职业，风险显著降低。尽管我们观察到一些社会经济地位较低的职业中前列腺癌风险增加，但总体结果表明，在职业因素与前列腺癌风险的关联中，不能排除较高社会经济地位的影响。
