Irgens A, Krüger K, Skorve A H, Irgens L M
Department of Occupational Medicine, Haukeland Hospital, Bergen, Norway.
Am J Ind Med. 1998 Nov;34(5):431-7. doi: 10.1002/(sici)1097-0274(199811)34:5<431::aid-ajim3>3.0.co;2-t.
In Norway, great efforts have been made to protect both male and female employees against teratogenic exposures. Associations between occupational lead exposure and reproductive outcome in the offspring were studied. All births in Norway 1970-1993 with possible maternal or paternal occupational lead exposure were compared with a reference population of offspring of parents without occupational lead exposure. Offspring of lead exposed mothers had an increased risk of low birth weight (RR = 1.34; CI = 1.12-1.60) and neural tube defects (RR = 2.87; CI = 1.05-6.38). Effects on birth weight and gestational age showed significant dose-response associations. Offspring of lead exposed fathers had no increased risks of any of the analyzed reproductive outcomes. However, decreased risks were observed of low birth weight (RR = 0.91; CI = 0.86-0.96) and preterm birth (RR = 0.89; CI = 0.86-0.93). Further efforts seem to be needed to protect the offspring of lead-exposed mothers.
在挪威，已做出巨大努力来保护男性和女性员工免受致畸性暴露。对职业性铅暴露与后代生殖结局之间的关联进行了研究。将1970年至1993年挪威所有可能有母亲或父亲职业性铅暴露的分娩情况与父母无职业性铅暴露的后代参考人群进行了比较。铅暴露母亲的后代出生体重低的风险增加（相对风险RR = 1.34；可信区间CI = 1.12 - 1.60）以及神经管缺陷的风险增加（RR = 2.87；CI = 1.05 - 6.38）。对出生体重和孕周的影响显示出显著的剂量反应关联。铅暴露父亲的后代在任何分析的生殖结局方面风险均未增加。然而，观察到出生体重低（RR = 0.91；CI = 0.86 - 0.96）和早产（RR = 0.89；CI = 0.86 - 0.93）的风险降低。似乎需要进一步努力来保护铅暴露母亲的后代。
