Alexander B H, Checkoway H, Faustman E M, van Netten C, Muller C H, Ewers T G
Department of Environmental Health, University of Washington, Seattle 98195, USA.
Am J Ind Med. 1998 Nov;34(5):464-9. doi: 10.1002/(sici)1097-0274(199811)34:4<464::aid-ajim20>3.0.co;2-z.
While blood lead concentration has been inversely associated with indicators of reproductive health in occupationally exposed male workers, the utility of lead concentration in semen as an indicator of lead exposure to the male reproductive system has not been fully explored. Blood and semen lead concentrations from 81 lead smelter workers were examined in relation to semen quality and endocrine function parameters. Mean blood and semen lead concentrations were 22.8 micrograms/dl (range 5-58) and 1.9 micrograms/dl (range 0.1-17.6), respectively. Total sperm count and concentration decreased with increasing blood lead concentration; p for trend was 0.003 and 0.009, respectively. Semen lead concentration was inversely related to total sperm count (p = 0.05), ejaculate volume (p = 0.001), and serum testosterone (p = 0.004), but not to sperm concentration. The association between semen lead concentration and total sperm count was eliminated when volume was included in the model. Blood lead concentration was more consistently associated with indicators of sperm production than was semen lead. In contrast, semen lead concentration was negatively associated with circulating testosterone concentrations. Our findings indicate that measurement of semen lead may not be a valuable adjunct to conventional blood lead monitoring for investigations of male reproductive system toxicity.
虽然血铅浓度与职业暴露男性工人的生殖健康指标呈负相关，但精液中的铅浓度作为男性生殖系统铅暴露指标的效用尚未得到充分探索。对81名铅冶炼工人的血液和精液铅浓度进行了检测，并与精液质量和内分泌功能参数进行了关联分析。血液和精液铅浓度的平均值分别为22.8微克/分升（范围5-58）和1.9微克/分升（范围0.1-17.6）。随着血铅浓度的升高，精子总数和浓度下降；趋势检验的p值分别为0.003和0.009。精液铅浓度与精子总数（p = 0.05）、射精量（p = 0.001）和血清睾酮（p = 0.004）呈负相关，但与精子浓度无关。当将射精量纳入模型时，精液铅浓度与精子总数之间的关联消失。血铅浓度比精液铅浓度更一致地与精子生成指标相关。相比之下，精液铅浓度与循环睾酮浓度呈负相关。我们的研究结果表明，对于男性生殖系统毒性的调查，精液铅检测可能不是传统血铅监测的有价值辅助手段。
