Koko J, Dufillot D, M'Ba-Meyo J, Gahouma D, Kani F
Service de pédiatrie générale, hôpital pédiatrique d'Owendo (HPO), Libreville, Gabon.
Arch Pediatr. 1998 Sep;5(9):965-9. doi: 10.1016/s0929-693x(98)80003-1.
Sickle cell disease is a serious public health problem in Gabon with a relatively high mortality rate.
Charts of 23 children (nine boys, 14 girls) who died of complications from sickle cell anemia in the department of pediatrics of Owendo Pediatric Hospital (Libreville, Gabon), from January 1, 1990 through December 31, 1992, were analysed retrospectively.
Approximately two-thirds of the children (60.9%) were under 5 years of age. The great majority of patients were from low socio-economic standard families. Of 319 deaths observed during the study period, 23 were due to sickle cell disease-associated complications, for an overall mortality rate of 7.2% and a related mortality of 3.6%. Commonest causes of deaths were severe anemia (11 cases, i.e., 47.8%), which affected predominantly the younger patients between 6 months and 5 years (eight cases), infections (30.4%) and blood transfusion complications (21.7%).
To decrease these mortality rates, appropriate health supervision and well-designed preventive strategies are needed.
镰状细胞病在加蓬是一个严重的公共卫生问题，死亡率相对较高。
对1990年1月1日至1992年12月31日期间在奥温多儿童医院（加蓬利伯维尔）儿科死于镰状细胞贫血并发症的23名儿童（9名男孩，14名女孩）的病历进行回顾性分析。
约三分之二的儿童（60.9%）年龄在5岁以下。绝大多数患者来自社会经济水平较低的家庭。在研究期间观察到的319例死亡中，23例死于镰状细胞病相关并发症，总死亡率为7.2%，相关死亡率为3.6%。最常见的死亡原因是严重贫血（11例，即47.8%），主要影响6个月至5岁的较年轻患者（8例）、感染（30.4%）和输血并发症（21.7%）。
为降低这些死亡率，需要适当的健康监督和精心设计的预防策略。
