Birth of healthy children after intracytoplasmic sperm injection in two couples with male Kartagener's syndrome.

OBJECTIVE

To describe two cases in which intracytoplasmic sperm injection (ICSI) was successful for patients with infertility due to Kartagener's syndrome.

DESIGN

Case report.

SETTING

Private hospital for gynecology department of reproductive medicine, and university hospital center for andrology.

PATIENT(S): Two couples with primary infertility due to Kartagener's syndrome in the male.

INTERVENTION(S): ICSI.

MAIN OUTCOME MEASURE(S): Pregnancy and birth after ICSI.

RESULT(S): In both couples, ICSI was successful in the first cycle. The uncomplicated pregnancies resulted in the birth of three healthy children. One female and male/female twins.

CONCLUSION(S): In couples with infertility due to Kartagener's syndrome in the male, ICSI has proved to be a successful therapy resulting in clinically healthy offspring. This knowledge may improve our understanding of the involvement of paternally inherited centrosomes, which nucleate microtubules, in human reproduction.