Biguzzi E, Mozzi E, Alatri A, Taioli E, Moia M, Mannucci P M
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy.
Thromb Haemost. 1998 Oct;80(4):575-7.
Post-thrombotic syndrome (PTS) in young women may cause impairment in the quality of life of otherwise healthy people. We aimed to evaluate the prevalence of PTS and its risk factors in young women. We evaluated 51 women with at least one previous episode of symptomatic, objectively documented deep vein thrombosis (DVT) before the age of 40. Each patient asked for symptoms had a physical examination, a color-coded Doppler ultrasonography of the superficial and deep venous system and an extensive laboratory evaluation for the congenital and acquired coagulation abnormalities predisposing to thrombosis. The median follow-up was 47 months. PTS was absent in 37%, mild in 55%, moderate in 4% and severe in 4% of patients. No correlation was found between PTS and the presence of coagulation abnormalities, triggering factors, recurrences, use of elastic stockings for one year after DVT, degree of recanalization, presence of superficial reflux. Patients with a body mass index (BMI) >22 had an adjusted ratio of 4.7 (98 CI: 1.0-23.3) of developing the PTS. Though severe and moderate PTS are rare, mild PTS is present in the majority of young women after DVT. A BMI >22 is associated to the risk of developing PTS. Attempt to control weight in women after DVT should be considered and studied to prevent PTS.
年轻女性的血栓形成后综合征（PTS）可能会损害原本健康人群的生活质量。我们旨在评估年轻女性中PTS的患病率及其危险因素。我们对51名在40岁之前至少有过一次有症状、经客观记录的深静脉血栓形成（DVT）发作的女性进行了评估。每位有症状的患者都接受了体格检查、浅静脉和深静脉系统的彩色编码多普勒超声检查，以及针对易导致血栓形成的先天性和获得性凝血异常的广泛实验室评估。中位随访时间为47个月。37%的患者无PTS，55%为轻度，4%为中度，4%为重度。未发现PTS与凝血异常的存在、触发因素、复发、DVT后使用弹力袜一年、再通程度、浅静脉反流的存在之间存在相关性。体重指数（BMI）>22的患者发生PTS的调整比值为4.7（98%CI：1.0-23.3）。虽然重度和中度PTS很少见，但大多数年轻女性在发生DVT后存在轻度PTS。BMI>22与发生PTS的风险相关。应考虑并研究对DVT后女性进行体重控制以预防PTS。
