Maguire R A, Zacharopoulos V R, Phillips D M
Population Council, New York, New York 10021, USA.
Sex Transm Dis. 1998 Oct;25(9):494-500. doi: 10.1097/00007435-199810000-00010.
Carrageenan-based nonoxynol-9 (N-9)-containing formulations were developed in response to the concern that over the counter (OTC) spermicides may not protect people from HIV infection and other sexually transmitted pathogens.
The goal of this study was to compare the efficacy of carrageenan-based formulations to OTC spermicides in protecting mice from infection by herpes simplex virus 2 (HSV-2).
Mice were challenged with vaginal inoculation of HSV-2 after pretreatment with test formulations.
Carrageenan-based formulations were significantly more effective than currently marketed spermicides containing the same amount of N-9. Efficacy was demonstrated over a wide pH range. The carrageenan-based formulations could be autoclaved without losing antiviral activity and remained active in the vagina for several hours.
We conclude that carrageenan-based N-9 formulations are likely to provide a more significant degree of protection against HSV-2 and other enveloped viruses than current OTC spermicides while providing comparable spermicidal activity.
鉴于非处方（OTC）杀精剂可能无法保护人们免受艾滋病毒感染和其他性传播病原体的侵害，研发了基于角叉菜胶的含壬苯醇醚-9（N-9）制剂。
本研究的目标是比较基于角叉菜胶的制剂与OTC杀精剂在保护小鼠免受单纯疱疹病毒2型（HSV-2）感染方面的效果。
用测试制剂预处理小鼠后，通过阴道接种HSV-2对其进行攻击。
基于角叉菜胶的制剂比目前市场上含等量N-9的杀精剂显著更有效。在很宽的pH范围内都显示出有效性。基于角叉菜胶的制剂可以进行高压灭菌而不丧失抗病毒活性，并且在阴道内保持活性数小时。
我们得出结论，基于角叉菜胶的N-9制剂可能比目前的OTC杀精剂在预防HSV-2和其他包膜病毒方面提供更显著程度的保护，同时提供相当的杀精活性。
