Cassatella M A
Department of Pathology, University of Verona, Italy.
Int J Clin Lab Res. 1998;28(3):148-61. doi: 10.1007/s005990050036.
Interleukin-10 exerts a wide spectrum of in vitro and in vivo biological activities implicated in the regulation of the inflammatory and immune responses. Among the different cell types affected by interleukin-10, monocyte/macrophages and lymphocytes appear to be particularly modified with regard to their function, morphology, and phenotype. However, recent studies performed in our laboratory, as well as by other groups, suggest that a number of functional activities of polymorphonuclear neutrophils are also subject to regulation by interleukin-10. In view of the central role of polymorphonuclear neutrophils in host defense processes and in amplifying inflammatory and immune reactions, the ability of interleukin-10 to act as a potent modulator of this cell type opens new perspectives as to the potential therapeutic utility of interleukin-10. This article reviews what is currently known about the effects of interleukin-10 on neutrophils.
白细胞介素-10具有广泛的体外和体内生物学活性，参与炎症和免疫反应的调节。在受白细胞介素-10影响的不同细胞类型中，单核细胞/巨噬细胞和淋巴细胞在功能、形态和表型方面似乎受到特别的改变。然而，我们实验室以及其他研究小组最近进行的研究表明，多形核中性粒细胞的许多功能活动也受到白细胞介素-10的调节。鉴于多形核中性粒细胞在宿主防御过程以及放大炎症和免疫反应中的核心作用，白细胞介素-10作为这种细胞类型的有效调节剂的能力为白细胞介素-10的潜在治疗用途开辟了新的前景。本文综述了目前已知的白细胞介素-10对中性粒细胞的影响。
