Hurlen M, Seljeflot I, Arnesen H
Department of Cardiology, Ullevål University Hospital, Oslo, Norway.
Scand Cardiovasc J. 1998;32(4):233-7. doi: 10.1080/14017439850140021.
Platelet aggregate ratio (PAR) was measured according to the method of Wu & Hoak in 143 patients after acute myocardial infarction (AMI) and in 54 controls. A PAR < 1 expresses the presence of platelet aggregates. The patients were randomized to aspirin 160 mg/d, or warfarin, or aspirin 75 mg/d + warfarin. In patients on aspirin, PAR was measured 24 h after aspirin intake, and in 76 patients also 2 h after aspirin. The median PAR in patients on warfarin was 0.85, on warfarin + aspirin 0.91 and on aspirin alone 0.94, all significantly lower than the median PAR of 0.97 in the controls. In 14 patients on aspirin the PARs were below a cut-off point of 0.82 (secondary aspirin non-responders). PAR increase significantly 2 h after aspirin intake. In two patients, however, PAR remained low (primary aspirin non-responders). It is concluded that some patients do not seem to respond to aspirin, the clinical implication of which has yet to be determined.
采用Wu和Hoak的方法，对143例急性心肌梗死（AMI）患者和54例对照者测定血小板聚集率（PAR）。PAR<1表示存在血小板聚集。患者被随机分为服用160mg/d阿司匹林组、华法林组或75mg/d阿司匹林+华法林组。服用阿司匹林的患者，在服用阿司匹林24小时后测定PAR，76例患者还在服用阿司匹林2小时后测定。服用华法林患者的PAR中位数为0.85，服用华法林+阿司匹林患者为0.91，单独服用阿司匹林患者为0.94，均显著低于对照组的PAR中位数0.97。14例服用阿司匹林的患者PAR低于0.82的临界点（继发性阿司匹林无反应者）。服用阿司匹林2小时后PAR显著升高。然而，有2例患者PAR仍较低（原发性阿司匹林无反应者）。得出的结论是，一些患者似乎对阿司匹林无反应，其临床意义尚待确定。
