Juhl J H
Altern Med Rev. 1998 Oct;3(5):367-75.
Fibromyalgia syndrome is a musculoskeletal pain and fatigue disorder manifested by diffuse myalgia, localized areas of tenderness, fatigue, lowered pain thresholds, and nonrestorative sleep. Evidence from multiple sources support the concept of decreased flux through the serotonin pathway in fibromyalgia patients. Serotonin substrate supplementation, via L-tryptophan or 5-hydroxytryptophan (5-HTP), has been shown to improve symptoms of depression, anxiety, insomnia and somatic pains in a variety of patient cohorts. Identification of low serum tryptophan and serotonin levels may be a simple way to identify persons who will respond well to this approach.
纤维肌痛综合征是一种肌肉骨骼疼痛和疲劳障碍，表现为弥漫性肌痛、局部压痛、疲劳、疼痛阈值降低和睡眠不能恢复体力。来自多个来源的证据支持纤维肌痛患者血清素途径通量降低的概念。通过L-色氨酸或5-羟色氨酸（5-HTP）补充血清素底物已被证明可改善各种患者群体的抑郁、焦虑、失眠和躯体疼痛症状。识别低血清色氨酸和血清素水平可能是一种简单的方法，用以识别对这种治疗方法反应良好的人群。
