Stahl S M
Department of Psychiatry, University of California at San Diego 92122, USA.
Psychopharmacol Bull. 1998;34(3):319-21.
Depression is a frequent problem in women who are candidates for receiving estrogen replacement therapy during perimenopause and menopause. However, there are no guidelines on how to optimize antidepressant administration with estrogen, especially in women insufficiently responsive to antidepressants. Neurobiological actions of estrogen as well as clinical observations of estrogen effects on mood suggest that more research is needed to help guide the use of estrogen concomitantly with antidepressants.
抑郁症是围绝经期和绝经期间接受雌激素替代疗法的女性中常见的问题。然而，关于如何与雌激素优化抗抑郁药给药，尤其是对抗抑郁药反应不足的女性，尚无指南。雌激素的神经生物学作用以及雌激素对情绪影响的临床观察表明，需要更多研究来指导抗抑郁药与雌激素的联合使用。
