Ryley J F, Wilson R G
Parasitology. 1976 Oct;73(2):137-48. doi: 10.1017/s0031182000046825.
Methods for screening compounds against Eimeria tenella in cell culture and in the chicken are described. An analysis for incidence of anticoccidial activity and host cell toxicity has been made of 11550 compounds screened in vitro, and some correlation of activity in vitro and in vivo has been attempted. The results show that screening compounds in tissue (cell) culture is not a satisfactory or reliable alternative to screening in chickens, although in vitro studies undoubtedly have a part to play in the evaluation of an active drug.
描述了在细胞培养和鸡体内筛选抗柔嫩艾美耳球虫化合物的方法。对在体外筛选的11550种化合物进行了抗球虫活性和宿主细胞毒性发生率的分析，并尝试了体外和体内活性之间的一些相关性研究。结果表明，在组织（细胞）培养中筛选化合物并非是在鸡体内筛选的令人满意或可靠的替代方法，尽管体外研究无疑在活性药物的评估中具有一定作用。
