Kasiske B L, London W, Ellison M D
Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USA.
J Am Soc Nephrol. 1998 Nov;9(11):2142-7. doi: 10.1681/ASN.V9112142.
This cohort study investigates whether there are inequities in the current system for listing patients for cadaveric renal transplantation, using univariate and multivariate analyses to identify factors associated with early registration before initiation of dialysis. It includes patient registrations for the kidney and kidney-pancreas waiting lists between April 1, 1994, and June 30, 1996 (n = 41,596) from all 238 United Network for Organ Sharing renal transplant centers. Patient and center factors predicting dialysis status (pre- or postdialysis initiation) at the time of registration were examined. Independent predictors of listing before dialysis (P < 0.001) included: female (odds ratio [OR] = 1.14, reference: male, i.e., listing before dialysis was 14% more likely in females than in males); age < or =17 and age 18 to 55 (OR = 1.91 and 1.14, respectively, reference: age >55); prior transplant (OR = 1.80, reference: no prior transplant); 0 to 8 yr education, attended college, and received a college degree (OR = 0.78, 1.18, and 1.37, respectively, reference: high school degree); black race, Hispanic, and Asian/other (OR = 0.47, 0.59, and 0.55, reference: white); full-time employment (OR = 1.98, reference: less than full time); payment with Medicare and private insurance (OR = 0.35 and 1.24, respectively, reference: other pay); receiving insulin (OR = 1.29, reference; not on insulin); listed for kidney-pancreas (OR = 1.43, reference: listed for kidney only); listed at a center with volume >400 (OR = 1.22, reference: volume <400). To remove possible bias for general access to health care and referral for transplantation, the analysis was limited to patients who had a previous transplant and found similar results. It is concluded that racial and ethnic minorities, those less well educated, and those with fewer financial resources are less likely than their counterparts to be listed for renal transplantation before dialysis. These results suggest there may be remediable inequities in the current system for registration for renal transplantation in the United States. Education efforts directed at patients and providers, as well as recently mandated uniform listing criteria for cadaveric organ transplantation, may help to reduce these inequities.
这项队列研究调查了当前尸体肾移植患者排队系统中是否存在不公平现象,采用单变量和多变量分析来确定与透析开始前早期登记相关的因素。研究纳入了1994年4月1日至1996年6月30日期间美国器官共享联合网络(United Network for Organ Sharing)所有238个肾移植中心的41596例肾脏及肾 - 胰联合移植等待名单上的患者登记信息。研究人员检查了登记时预测透析状态(透析开始前或开始后)的患者及中心因素。透析前登记的独立预测因素(P < 0.001)包括:女性(优势比[OR] = 1.14,参照组:男性,即女性透析前登记的可能性比男性高14%);年龄≤17岁以及18至55岁(OR分别为1.91和1.14,参照组:年龄>55岁);曾接受过移植(OR = 1.80,参照组:未曾接受过移植);接受0至8年教育、上过大学以及获得大学学位(OR分别为0.78、1.18和1.37,参照组:高中学历);黑人、西班牙裔以及亚裔/其他族裔(OR分别为0.47、0.59和0.55,参照组:白人);全职工作(OR = 1.98,参照组:非全职工作);使用医疗保险和私人保险支付费用(OR分别为0.35和1.24,参照组:其他支付方式);接受胰岛素治疗(OR = 1.29,参照组:未使用胰岛素);登记为肾 - 胰联合移植(OR = 1.43,参照组:仅登记肾脏移植);登记于移植量>400例的中心(OR = 1.22,参照组:移植量<400例)。为消除一般医疗保健获取和移植转诊可能存在的偏差,分析仅限于曾接受过移植的患者,结果相似。研究得出结论,少数族裔、受教育程度较低者以及经济资源较少者相比其他人,在透析前进行肾移植登记的可能性更低。这些结果表明,美国当前的肾移植登记系统可能存在可纠正的不公平现象。针对患者和医疗服务提供者的教育努力,以及最近强制规定的尸体器官移植统一排队标准,可能有助于减少这些不公平现象。