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The Escherichia coli cmlA gene encodes the multidrug efflux pump Cmr/MdfA and is responsible for isopropyl-beta-D-thiogalactopyranoside exclusion and spectinomycin sensitivity.大肠杆菌cmlA基因编码多药外排泵Cmr/MdfA，并负责异丙基-β-D-硫代半乳糖苷的排除和壮观霉素敏感性。
J Bacteriol. 1998 Nov;180(22):6072-5. doi: 10.1128/JB.180.22.6072-6075.1998.
2
Escherichia coli gene ydeA encodes a major facilitator pump which exports L-arabinose and isopropyl-beta-D-thiogalactopyranoside.大肠杆菌基因ydeA编码一种主要易化子泵，该泵可输出L-阿拉伯糖和异丙基-β-D-硫代半乳糖苷。
J Bacteriol. 1999 Aug;181(16):5123-5. doi: 10.1128/JB.181.16.5123-5125.1999.
3
Evidence for chloramphenicol/H+ antiport in Cmr (MdfA) system of Escherichia coli and properties of the antiporter.大肠杆菌Cmr（MdfA）系统中氯霉素/H⁺反向转运的证据及反向转运体的特性。
J Biochem. 1998 Jul;124(1):187-93. doi: 10.1093/oxfordjournals.jbchem.a022078.
4
Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli.AcrAB、MdfA和NorE外排泵对大肠杆菌喹诺酮耐药性的相对贡献。
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Characterization of SotA and SotB, two Erwinia chrysanthemi proteins which modify isopropyl-beta-D-thiogalactopyranoside and lactose induction of the Escherichia coli lac promoter.对SotA和SotB这两种菊欧文氏菌蛋白的特性分析，这两种蛋白可改变异丙基-β-D-硫代半乳糖苷和乳糖对大肠杆菌乳糖启动子的诱导作用。
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Efflux of chloramphenicol by the CmlA1 protein.氯霉素通过CmlA1蛋白流出。
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The effect of the lacY gene on the induction of IPTG inducible promoters, studied in Escherichia coli and Pseudomonas fluorescens.在大肠杆菌和荧光假单胞菌中研究了lacY基因对IPTG诱导型启动子诱导作用的影响。
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Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli.有证据表明，TolC是大肠杆菌Mar/AcrAB外排泵发挥功能所必需的。
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Structural and environmental features of novel mdfA variant and mdfA genes in recombinant regions of Escherichia coli.大肠杆菌重组区域中新型mdfA变体和mdfA基因的结构与环境特征
Microb Drug Resist. 2014 Oct;20(5):392-8. doi: 10.1089/mdr.2013.0201. Epub 2014 Mar 31.
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AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants.AcrAB外排泵在大肠杆菌多重耐药（Mar）突变体的抗生素耐药表型中起主要作用。
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本文引用的文献

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Lactococcus lactis phage operon coding for an endonuclease homologous to RuvC.编码与RuvC同源的核酸内切酶的乳酸乳球菌噬菌体操纵子。
Mol Microbiol. 1998 May;28(4):823-34. doi: 10.1046/j.1365-2958.1998.00845.x.
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A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene.一种可补充人类多药耐药性P-糖蛋白基因的细菌抗生素抗性基因。
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Mechanisms of multidrug transporters.多药转运蛋白的机制。
FEMS Microbiol Rev. 1997 Aug;21(1):55-84. doi: 10.1111/j.1574-6976.1997.tb00345.x.
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The complete genome sequence of Escherichia coli K-12.大肠杆菌K-12的全基因组序列。
Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
5
Impaired lysogenisation of the Escherichia coli rpoA341 mutant by bacteriophage lambda is due to the inability of CII to act as a transcriptional activator.噬菌体λ对大肠杆菌rpoA341突变体的溶原化受损是由于CII无法作为转录激活因子发挥作用。
Mol Gen Genet. 1997 Apr 16;254(3):304-11. doi: 10.1007/s004380050420.
6
MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition.MdfA是一种大肠杆菌多药耐药蛋白，具有极其广泛的药物识别谱。
J Bacteriol. 1997 Apr;179(7):2274-80. doi: 10.1128/jb.179.7.2274-2280.1997.
7
Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.由人类多药转运蛋白MDR1的细菌同源物介导的多药耐药性。
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10668-72. doi: 10.1073/pnas.93.20.10668.
8
Multidrug efflux pumps of gram-negative bacteria.革兰氏阴性菌的多药外排泵
J Bacteriol. 1996 Oct;178(20):5853-9. doi: 10.1128/jb.178.20.5853-5859.1996.
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The tolZ gene of Escherichia coli is identified as the ftsH gene.大肠杆菌的tolZ基因被鉴定为ftsH基因。
J Bacteriol. 1996 Jun;178(12):3457-61. doi: 10.1128/jb.178.12.3457-3461.1996.
10
Isolation of cmr, a novel Escherichia coli chloramphenicol resistance gene encoding a putative efflux pump.cmr的分离，cmr是一种新型大肠杆菌氯霉素抗性基因，编码一种假定的外排泵。
J Bacteriol. 1996 Jun;178(11):3188-93. doi: 10.1128/jb.178.11.3188-3193.1996.

大肠杆菌cmlA基因编码多药外排泵Cmr/MdfA，并负责异丙基-β-D-硫代半乳糖苷的排除和壮观霉素敏感性。

The Escherichia coli cmlA gene encodes the multidrug efflux pump Cmr/MdfA and is responsible for isopropyl-beta-D-thiogalactopyranoside exclusion and spectinomycin sensitivity.

作者信息

Bohn C, Bouloc P

机构信息

Laboratoire des Réseaux de Régulations, Institut de Génétique et Microbiologie, Université Paris-Sud, CNRS/URA2225, F-91405 Orsay Cedex, France.

出版信息

J Bacteriol. 1998 Nov;180(22):6072-5. doi: 10.1128/JB.180.22.6072-6075.1998.

DOI:10.1128/JB.180.22.6072-6075.1998
PMID:9811673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC107689/
Abstract

Expression of cloned genes from isopropyl-beta-D-thiogalactopyranoside (IPTG)-regulated promoters is lowered when the Escherichia coli CmlA/Cmr/MdfA efflux pump is overexpressed, probably due to IPTG exclusion from the cytoplasm. The previously reported cmlA1 mutation confers a similar phenotype. cmlA1 contains an IS30 insertion upstream of cmr/mdfA, which creates a putative promoter. CmlA overproduction also causes spectinomycin hypersensitivity.

摘要

当大肠杆菌CmlA/Cmr/MdfA外排泵过表达时，来自异丙基-β-D-硫代半乳糖苷（IPTG）调控启动子的克隆基因的表达会降低，这可能是由于IPTG被排除在细胞质之外。先前报道的cmlA1突变赋予了类似的表型。cmlA1在cmr/mdfA上游含有一个IS30插入序列，该序列产生一个推定的启动子。CmlA的过量产生也会导致对壮观霉素过敏。