[1992 - 1995年中国云南省瑞丽市及其他两县静脉吸毒者中HIV感染的队列研究]

[A cohort study of HIV infection among intravenous drug users in Ruili and other two counties in Yunnan Province, China, 1992-1995].

作者信息

Zheng X, Zhang J P, Qu S Q

机构信息

Institute of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine, Beijing.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1997 Oct;18(5):259-62.

PMID:9812484

Abstract

Since 1992, cohort study of prevaience of HIV infection and incidence rate among drug users has been conducted annually at the study spots along southwestern border areas of Ruili, Longchuan and Luxi counties, Yunnan province of China. From 1992 to 1995, 859, 437, 343 and 540 drug users with a total number of 2179 cases were studied respectively. The proportion of IDUs among drug users was about 30% in 1992, and went up to about 50% in 1995. HIV serloprevalence rates among IDUs in Ruili was comparatively high. From 1992 to 1995, the rates were 81.8%, 85.7%, 61.8% and 51.9% respectively. Longchuan county was at medium, 44.6%, 40.0%, 42.2% and 43.5% respectively. Luxi kept at a lower level, which were 5.1%, 0%, 0% and 3.1%. From 1992 to 1995, the increase of incidence rates were 30.1% from 21.7% to 42.1% in Ruili county, 17.2% (12.1% to 25.9%) in Long Chuan, and 0.6% (0% to 2.3%) in Luxi. The sero-prevalence rate among the spouses of these HIV infected persons was 3.1% in 1990, but increased to 9.8%, 7.4%, 0% and 10.3% respectively from 1992 to 1995 and was 12.3% in 1997. CD4 counting was conducted in 107 cases. The result indicated at the earlier of the year being infected. The higher proportion of CD4 count which was < 500/mm3 on NASBA was applied to analyse the viral load, 3 out of 29 cases were < 1,000 copies/ml, while Log mean of viral load in 26 cases was 4.37.

摘要

自1992年起，每年在中国云南省瑞丽、陇川和潞西三县的西南边境地区的研究点开展吸毒人群中艾滋病毒感染流行率和发病率的队列研究。1992年至1995年，分别对859名、437名、343名和540名吸毒人员进行了研究，共计2179例。1992年吸毒人员中注射吸毒者的比例约为30%，到1995年上升至约50%。瑞丽注射吸毒者中的艾滋病毒血清流行率相对较高。1992年至1995年，该比率分别为81.8%、85.7%、61.8%和51.9%。陇川县处于中等水平，分别为44.6%、40.0%、42.2%和43.5%。潞西维持在较低水平，分别为5.1%、0%、0%和3.1%。1992年至1995年，发病率的增幅在瑞丽县为30.1%（从21.7%升至42.1%），陇川县为17.2%（从12.1%升至25.9%），潞西县为0.6%（从0%升至2.3%）。这些艾滋病毒感染者配偶中的血清流行率在1990年为3.1%，但从1992年至1995年分别升至9.8%、7.4%、0%和10.3%，1997年为12.3%。对107例进行了CD4计数。结果表明在感染当年早期。应用NASBA对病毒载量进行分析时，CD4计数<500/mm3的比例较高，29例中有3例<1000拷贝/ml，而26例病毒载量的对数平均值为4.37。