一种测定人血浆中阿米替林和去甲替林的灵敏方法。
A sensitive method for the determination of amitriptyline and nortriptyline in human plasma.
作者信息
Cooper T B, Allen D, Simpson G M
出版信息
Psychopharmacol Commun. 1976;2(2):105-16.
PMID:981709
Abstract
A highly sensitive and reproducible GLC technique for the quantitation of amitriptyline and nortriptyline is described. The lower limit of detection is less than 1 ng/ml. 5 ng/ml samples (3 ml aliquots) can be accurately quantified (C of V less than 5%). Steady state data are reported together with data on amitriptyline and nortriptyline levels obtained in a volunteer who ingested a single oral dose (25 mg) of amitriptyline (Elavil).
摘要
本文描述了一种用于定量阿米替林和去甲替林的高灵敏度且可重复的气相色谱法。检测下限小于1纳克/毫升。5纳克/毫升的样品（3毫升等分试样）能够被准确定量（变异系数小于5%）。文中报告了稳态数据以及在一名志愿者口服单次剂量（25毫克）阿米替林（依拉维）后获得的阿米替林和去甲替林水平的数据。
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