阿米替林和去甲替林的特异性放射免疫测定
Specific radioimmunoassay of amitriptyline and nortriptyline.
作者信息
Brunswick D J, Needelman B, Mendels J
出版信息
Br J Clin Pharmacol. 1979 Apr;7(4):343-8. doi: 10.1111/j.1365-2125.1979.tb00943.x.
Abstract
1 Antisera to nortriptyline were prepared by immunizing rabbits with N-succinylnortriptyline--bovine serum albumin conjugate. 2 A sensitive radioimmunoassay has been developed for the tricyclic antidepressants amitriptyline and nortriptyline. 3 amitriptyline and nortriptyline are separated from each other and from interfering metabolites before assay. 4 Using [3H]-imipramine and [3H]-succinylnortriptyline as tracers the radioimmunoassay can measure amitriptyline and nortriptyline levels down to 2--3 ng/ml using 0.05 ml plasma sample. 5 Agreement between the radioimmunoassay and a gas-chromatographic assay was excellent for both amitriptyline and nortriptyline.
摘要
- 通过用N-琥珀酰去甲替林-牛血清白蛋白偶联物免疫兔子制备了去甲替林抗血清。2. 已开发出一种用于三环类抗抑郁药阿米替林和去甲替林的灵敏放射免疫测定法。3. 在测定前，将阿米替林和去甲替林彼此分离，并与干扰代谢物分离。4. 使用[3H]-丙咪嗪和[3H]-琥珀酰去甲替林作为示踪剂，放射免疫测定法使用0.05 ml血浆样本可测量低至2-3 ng/ml的阿米替林和去甲替林水平。5. 放射免疫测定法与气相色谱测定法之间对于阿米替林和去甲替林的一致性都非常好。
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Specific radioimmunoassay of amitriptyline and nortriptyline.阿米替林和去甲替林的特异性放射免疫测定
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本文引用的文献
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Metabolism of tricyclic antidepressants. A review.三环类抗抑郁药的代谢。综述。
Dan Med Bull. 1974 Oct;21(6):218-31.
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Plasma nortriptyline and clinical response.血浆去甲替林与临床反应。
Clin Pharmacol Ther. 1974 Oct;16(4):639-44. doi: 10.1002/cpt1974164639.
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Plasma nortriptyline levels--relationship to clinical effects.血浆去甲替林水平——与临床疗效的关系
Clin Pharmacol Ther. 1974 Jul;16(1):215-29.
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Method for the determination of tracer antigen specific activity by radioimmunoassay.通过放射免疫测定法测定示踪抗原比活性的方法。
Immunochemistry. 1974 Sep;11(9):611-13. doi: 10.1016/0019-2791(74)90254-7.
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Plasma concentration of amitriptyline and clinical response.阿米替林的血浆浓度与临床反应。
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A gas chromatographic method for the determination of amitriptyline and nortriptyline in human serum.一种用于测定人血清中阿米替林和去甲替林的气相色谱法。
Acta Pharmacol Toxicol (Copenh). 1975 Jan;36(1):79-90.
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Thymoleptic and neuroleptic drug plasma levels in psychiatry: current status.精神病学中抗抑郁药和抗精神病药的血浆水平：现状
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