Klapdor R
Res Exp Med (Berl). 1976 Oct 29;168(3):203-11. doi: 10.1007/BF01851318.
The influence of a phenobarbital pretreatment on the distribution and biliary excretion of Ioglycamide was studied in 6 experiments in the anaesthetized minipig. The phenobarbital pretreatment led to a significant increase of the biliary transportmaximum and the biliary concentration of Ioglycamide. A detailed analysis suggests a phenobarbital induced stimulation of the hepatocellular excretion. The applicability of a pretreatment with phenobarbital in order to improve the opacification of the biliary system during x-ray-examinations with Ioglycamide is discussed.
在6个实验中，研究了苯巴比妥预处理对碘甘酰胺在麻醉小型猪体内分布和胆汁排泄的影响。苯巴比妥预处理导致碘甘酰胺的胆汁转运最大值和胆汁浓度显著增加。详细分析表明，苯巴比妥可刺激肝细胞排泄。讨论了用苯巴比妥预处理以改善碘甘酰胺X线检查时胆道系统显影的适用性。
