Ohlerth S, Busato A, Gaillard C, Flückiger M, Lang J
Abteilung für Kleintierradiologie, Universität Bern.
Dtsch Tierarztl Wochenschr. 1998 Oct;105(10):378-83.
The occurrence of canine hip dysplasia (CHD) was analyzed in a colony of 738 Labrador Retrievers between 1972 and 1996. Of these dogs, 86.3% were radiographically examined for hip dysplasia. The overall prevalence of CHD was 31.3% during the study period of 25 years. Between 1972 and 1980, the prevalence of CHD was 57.9%. It decreased to 14.9% between 1991 and 1996. Univariate and multivariate logistic regression models were developed to identify the influence of potential risk factors for CHD such as age at examination, gender, color, year and season of birth, litter size, order of birth, birth weight, body weight and daily weight gain. Birth year and age at examination proved to be significant risk factors. No significant association was found between CHD and elbow dysplasia. Of the dogs diagnosed with CHD, 18% showed dysplastic changes only, without radiographic signs of secondary osteoarthritis (OA). The Norberg angle (NA) proved to be a significant risk factor for coxofemoral osteoarthritis with a moderate negative correlation between OA and NA. Finally, genetic effects were calculated in a mixed model. Heritability (h2) of CHD was estimated at 0.53 (SE = 0.17) for paternal half siblings. The proportion of the common environment of a litter to the total variance was estimated at C2 = 0.03.
对1972年至1996年间738只拉布拉多猎犬群体中犬髋关节发育不良（CHD）的发病情况进行了分析。在这些犬中，86.3%接受了髋关节发育不良的X线检查。在25年的研究期间，CHD的总体患病率为31.3%。1972年至1980年期间，CHD的患病率为57.9%。1991年至1996年期间降至14.9%。建立了单变量和多变量逻辑回归模型，以确定CHD潜在风险因素的影响，如检查时的年龄、性别、毛色、出生年份和季节、窝仔数、出生顺序、出生体重、体重和日增重。出生年份和检查时的年龄被证明是显著的风险因素。未发现CHD与肘关节发育不良之间存在显著关联。在被诊断为CHD的犬中，18%仅表现出发育不良变化，无继发性骨关节炎（OA）的X线征象。诺伯格角（NA）被证明是髋股关节炎的一个显著风险因素，OA与NA之间存在中度负相关。最后，在混合模型中计算了遗传效应。父系半同胞的CHD遗传力（h2）估计为0.53（标准误=0.17）。一窝犬共同环境对总方差的比例估计为C2 = 0.03。
