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用淋病奈瑟菌和解脲脲原体对雄性食蟹猴进行生殖器接种。

Genital inoculation of male Macaca fascicularis with Neisseria gonorrhoeae and Ureaplasma urealyticum.

作者信息

Bowie W R, Digiacomo R F, Holmes K K, Gale J L

出版信息

Br J Vener Dis. 1978 Aug;54(4):235-8. doi: 10.1136/sti.54.4.235.

DOI:10.1136/sti.54.4.235
PMID:98203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1045509/
Abstract

Inoculation of the urethra, conjunctiva, pharynx, and anal canal of six male crab-eating macaques (Macaca fascicularis) with urethral exudate from male patients with urethral gonorrhoea or with laboratory gonococcal strains was unsuccessful in establishing infection or producing increased polymorphonuclear leucocytes on Gram stain. Intraurethral inoculation with laboratory strains of Ureaplasma urealyticum resulted in transiently positive urethral cultures for U. urealyticum and was associated in some cases with increased numbers of polymorphonuclear leucocytes on Gram stain of urethral material. The findings suggest that the crab-eating macaque may be useful for studying the pathogenesis of urethral infection with U. urealyticum.

摘要

用男性尿道淋病患者的尿道渗出物或实验室淋病奈瑟菌菌株接种六只食蟹猕猴(食蟹猴)的尿道、结膜、咽部和肛管,未能成功建立感染或在革兰氏染色时产生更多的多形核白细胞。用解脲脲原体实验室菌株进行尿道内接种,导致解脲脲原体尿道培养物短暂呈阳性,在某些情况下,尿道材料革兰氏染色时多形核白细胞数量增加。这些发现表明,食蟹猕猴可能有助于研究解脲脲原体引起的尿道感染的发病机制。

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Tetracycline in nongonococcal urethritis. Comparison of 2 g and 1 g daily for seven days.四环素治疗非淋菌性尿道炎。每日2克与每日1克治疗七天的比较。
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本文引用的文献

1
Transfer of gonococcal urethritis from man to chimpanzee. An animal model for gonorrhea.淋菌性尿道炎从人到黑猩猩的传播。一种淋病的动物模型。
JAMA. 1971 Jun 7;216(10):1612-4.
2
Human intra-urethral inoculation of ureplasmas.人类尿道脲原体接种。
Q J Med. 1977 Jul;46(183):309-26.
3
Chlamydial infection of the male baboon urethra.雄性狒狒尿道的衣原体感染。
Br J Vener Dis. 1975 Oct;51(5):310-3. doi: 10.1136/sti.51.5.310.
4
Asymptomatic gonorrhea in men: caused by gonococci with unique nutritional requirements.男性无症状淋病:由具有独特营养需求的淋球菌引起。
Science. 1977 Jun 17;196(4296):1352-3. doi: 10.1126/science.405742.
5
Genital inoculation of male baboons with Neisseria gonorrhoeae.用淋病奈瑟菌对雄性狒狒进行生殖器接种。
Infect Immun. 1977 Feb;15(2):670-1. doi: 10.1128/iai.15.2.670-671.1977.
6
Etiology of nongonococcal urethritis. Evidence for Chlamydia trachomatis and Ureaplasma urealyticum.非淋菌性尿道炎的病因。沙眼衣原体和解脲脲原体的证据。
J Clin Invest. 1977 May;59(5):735-42. doi: 10.1172/JCI108694.
7
Etiology of nongonococcal urethritis.非淋菌性尿道炎的病因
N Engl J Med. 1975 Jun 5;292(23):1199-205. doi: 10.1056/NEJM197506052922301.
8
Differential response of chlamydial and ureaplasma-associated urethritis to sulphafurazole (sulfisoxazole) and aminocyclitols.衣原体和脲原体相关性尿道炎对磺胺异恶唑(磺胺甲恶唑)和氨基环醇的不同反应。
Lancet. 1976 Dec 11;2(7998):1276-8. doi: 10.1016/s0140-6736(76)92034-1.