Hukins D W, Knight D P, Woodhead-Galloway J
Science. 1976 Nov 5;194(4265):622-4. doi: 10.1126/science.982030.
High-angle x-ray diffraction provides direct evidence that amianthoid change, occurring during aging of costal cartilage, corresponds to a transformation from an isotropic to a marked anisotropic distribution of collagen fibrils. Low-angle x-ray diffraction and electron microscopy show that the fibrils have the customary 67-nanometer axial periodicity. Electron microscopy shows that wide amianthoid collagen fibrils consist of smaller parallel fibrils fused together. Similarities between amianthoid change and tendon morphogenesis are briefly discussed. Amianthoid change is remarkable in that aging is accompanied by increased order.
高角度X射线衍射提供了直接证据，表明肋软骨老化过程中发生的石棉样变化对应于胶原纤维从各向同性分布到明显各向异性分布的转变。低角度X射线衍射和电子显微镜显示，这些纤维具有常见的67纳米轴向周期性。电子显微镜显示，粗大的石棉样胶原纤维由融合在一起的较小平行纤维组成。文中简要讨论了石棉样变化与肌腱形态发生之间的相似性。石棉样变化很显著，因为老化伴随着有序度的增加。
