Harris C C, Autrup H, Connor R, Barrett L A, McDowell E M, Trump B F
Science. 1976 Dec 3;194(4269):1067-9. doi: 10.1126/science.982061.
The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.
在37例患者的标本中测量了苯并[a]芘与培养的人支气管中DNA的结合情况。结合值范围为每毫克DNA中苯并[a]芘2至151皮摩尔，总体平均值±标准误差为34.2±5.2。苯并[a]芘与DNA结合的个体间75倍差异在幅度上与药物代谢的药物遗传学研究中发现的相似。芳烃羟化酶也可被支气管黏膜中的苯并[a]蒽诱导。
